Skip to main content

Table 2 Evidence for cardiovascular effects of EPA, DHA and DPA in human sutdies

From: Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease

  EPA DHA DPA
Physiologic risk factors
Lipids ↓ TG levels ↓ TG levels
  ↓ HDL3 cholesterol2 ↑ LDL particle size  
   ↑ HDL2 cholesterol  
Vascular and cardiac hemodynamics Minimal BP effects ↓ BP
  ? Heart rate effects ↓ Heart rate  
↑ Cardiac diastolic filling2 ↑ Cardiac diastolic filling2  
↑ Arterial compliance2 ↑ Arterial compliance2  
Endothelial function No clear effects2 No clear effects2
Inflammation and oxidative ↓ Inflammation, mixed ↓ Inflammation, mixed ↓ Inflammation, mixed
stress results2 results2 results2,3
  ↓ Oxidative stress, mixed results2 ↓ Oxidative stress, mixed results2  
Thrombosis and coagulation ↓ Collagen-stimulated platelet aggregation2 ↓ Collagen-stimulated platelet aggregation2 ↓ Collagen-stimulated platelet aggregation2
  Otherwise minimal effects on thrombosis or coagulation Otherwise minimal effects on thrombosis or coagulation  
  1. 1. BP blood pressure, CHD Coronary heart disease, DPA docosapentaenoic, − minimal data available for direct assessment.
  2. 2. Base on a single study or few studies. 3. Observation studies only.
  3. Abbreviations: DHA docosahexaenoic acid, EPA eicosapentaenoic acid, DPA docosapentaenoic acid, TG Triglycerid, BP blood pressure, HDL high-density lipoprotein, LDL low-density lipoprotein, NO nitric oxide.
  4. Adapted from reference [43] Mozaffarian and Wu, 2012