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Table 6 Plasma fatty acid composition and desaturase activity index of controls, non-CAD and CAD patients

From: Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients

 

Controls (n = 120)

non-CAD patients (n = 39)

CAD patients (n = 111)

Total SFA

34.01 ± 5.27

37.23 ± 3.72**

37.14 ± 3.41**

lauric acid, 12:0

0.15 ± 0.12

0.24 ± 0.38

0.45 ± 0.80**

Tridecylic acid, 13:0

0.16 ± 0.25

0.33 ± 0.5*

0.36 ± 0.63**

myristic acid, 14:0

4.17 ± 1.39

3.43 ± 1.43*

3.64 ± 1.37*

pentadecylic acid, 15:0

0.3 ± 0.18

0.38 ± 0.18*

0.4 ± 0.25**

Palmitic acid, 16:0

15.65 ± 5.35

20.21 ± 3.02**

19.63 ± 3.39**

Stearic acid, 18:0

8.11 ± 1.47

8.26 ± 1.39

7.83 ± 1.17

Arachidic acid, 20:0

0.26 ± 0.20

0.29 ± 0.2

0.38 ± 0.32**

Behenic acid, 22:0

0.41 ± 0.28

0.30 ± 0.26*

0.44 ± 0.35

Tricosylic acid, 23:0

1.12 ± 0.58

0.44 ± 0.26*

0.91 ± 0.37*

Lignoceric acid, 24:0

0.25 ± 0.2

0.44 ± 0.26**

0.47 ± 0.35**

Cerotic acid, 26:0

3.4 ± 1.05

2.45 ± 0.97**

2.58 ± 1.07**

Total MUFA

20.25 ± 3.48

25.32 ± 3.57**

24.55 ± 3.28**

Myristoleic acid, 14:1n-5

0.97 ± 0.39

1.35 ± 0.39**

1.42 ± 0.57**

Palmitoleic acid, 16:1 n-5

1.33 ± 0.32

2.82 ± 1.1**

2.67 ± 0.88**

Oleic acid, 18:1n-9

13.18 ± 3.71

16.64 ± 3.37**

15.95 ± 3.28**

cis-Vaccenic acid, 18:1 n-7

2.21 ± 0.73

2.08 ± 0.48

2.08 ± 0.57

Eicosenoic acid, 20:1 n-9

0.8 ± 0.46

0.64 ± 0.26*

0.7 ± 0.37*

Erucic acid, 22:1n-9

0.38 ± 0.25

0.3 ± 0.32*

0.32 ± 0.21*

Nervonic acid, 24:1 n-9

1 ± 0.81

0.93 ± 0.97

0.86 ± 1.04*

Total PUFA

43.05 ± 5.9

33.92 ± 4.47**

34.12 ± 2.93**

Total PUFA n-3

4.47 ± 1.3

5.06 ± 1.16*

4.74 ± 1.44

Alpha-linolenic acid, 18:3n-3

0.47 ± 0.37

0.65 ± 0.51*

0.7 ± 0.54*

Eicosatrienoic acid, 20:3n-3

2.37 ± 0.71

2.48 ± 0.92

2.23 ± 1

Eicosapentaenoic acid, 20:5n-3

0.84 ± 0.77

1.06 ± 0.88*

0.96 ± 0.72*

Docosahexaenoic acid, 22:6n-3

0.78 ± 0.39

0.86 ± 0.44

0.84 ± 0.36

Total PUFA n-6

38.58 ± 6.26

28.86 ± 4.62**

29.38 ± 3.15**

Linoleic acid, 18:2n-6

31.89 ± 6.44

20.20 ± 4.78**

20.56 ± 3.371**

c-linolenic acid, 18:3n-6

0.65 ± 0.34

0.87 ± 0.35**

0.96 ± 0.42**

Dihomo-c-linolenic acid, 20:3n-6

0.49 ± 0.25

0.52 ± 0.2

0.57 ± 0.29

Arachidonic acid, 20:4n-6

5.55 ± 1.59

7.25 ± 2.02**

7.28 ± 1.77**

Total UFA

63.30 ± 5.24

59.25 ± 3.67**

58.67 ± 3.60**

Total PUFA/Total SFA

1.32 ± 0.37

0.92 ± 0.18**

0.93 ± 0.13**

Desaturation index

 20:4n-6/20:3n-6 (D5D)

13.28 ± 8.14

15.72 ± 7.47*

14.56 ± 6.8*

 20:4n-6/18:2n-6 (D6D)

0.18 ± 0.07

0.47 ± 0.43**

0.37 ± 0.13**

 18:3n-6/18:2n-6 (D6D)

0.02 ± 0.01

0.05 ± 0.07**

0.05 ± 0.02**

 16:1/16:0 (D9D-16)

0.09 ± 0.04

0.14 ± 0.05**

0.14 ± 0.05**

 18:1n-9/18:0 (D9D-18)

1.70 ± 0.66

2.07 ± 0.57**

2.08 ± 0.53**

 14:n-5/14:0

0.27 ± 0.16

0.62 ± 0.16**

0.42 ± 0.17**

SFA/UFA

0.54 ± 0.13

0.63 ± 0.10**

0.64 ± 0.17**

  1. Data are expressed as relative values (%): mean % of total Plasma fatty acid ± SD. A Mann Whitney test was used. Significant difference between controls and patients is indicated by *: p < 0.05 and **: p < 0.001. SFA: saturated fatty acid; MUFA: monounsaturated fatty acid; PUFA: polyunsaturated fatty acid; PUFA n-3: polyunsaturated n-3 fatty acid; PUFA n-6: polyunsaturated n-6 fatty acid; UFA: unsaturated fatty acids; C16:1/C16:0 and C18:1/C18:0: ∆9 desaturation index; C20:4/C18:2: ∆6 desaturation index; C20:4/C20:3: ∆5 desaturation index
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Lipids in Health and Disease

ISSN: 1476-511X