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Table 3 Lipid parameters and major cardiovascular events in IDEAL

From: Prediction of future cardiovascular disease with an equation to estimate apolipoprotein B in patients with high cardiovascular risk: an analysis from the TNT and IDEAL study

Variables

 

Baseline

12 week

1 year

2 year

3 year

4 year

5 year

N

SIMV

4445

4371

4290

4168

4033

3930

775

ATV

4435

4334

4198

4099

3985

3861

758

LDL cholesterol (mmol/L)

SIMV

3.14 (0.01)

2.71 (0.01)

2.64 (0.01)

2.68 (0.01)

2.75 (0.01)

2.68 (0.01)

2.58 (0.02)

ATV

3.15 (0.01)

2.01 (0.01)

2.05 (0.01)

2.12 (0.01)

2.22 (0.01)

2.16 (0.01)

2.07 (0.03)

HR

1.14 (1.07–1.20)

1.09 (1.03–1.16)

1.12 (1.05–1.19)

1.13 (1.06–1.20)

1.10 (1.03–1.18)

1.08 (1.01–1.16)

1.06 (0.91–1.25)

Non-HDL cholesterol (mmol/L)

SIMV

3.87 (0.02)

3.41 (0.01)

3.33 (0.01)

3.36 (0.01)

3.43 (0.01)

3.37 (0.01)

3.26 (0.03)

ATV

3.90 (0.02)

2.59 (0.01)

2.63 (0.01)

2.70 (0.01)

2.79 (0.01)

2.74 (0.01)

2.67 (0.03)

HR

1.15 (1.08–1.21)

1.10 (1.04–1.17)

1.15 (1.08–1.22)

1.18 (1.11–1.25)

1.12 (1.04–1.20)

1.11 (1.03–1.19)

1.07 (0.91–1.25)

Apolipoprotein B (g/L)

SIMV

1.19 (0.0)

1.05 (0.0)

1.07 (0.0)

1.03 (0.0)

1.06 (0.0)

1.09 (0.0)

1.08 (0.01)

ATV

1.19 (0.0)

0.80 (0.0)

0.84 (0.0)

0.82 (0.0)

0.86 (0.0)

0.90 (0.0)

0.91 (0.01)

HR

1.15 (1.09–1.22)

1.13 (1.06–1.19)

1.17 (1.10–1.24)

1.18 (1.11–1.26)

1.16 (1.08–1.24)

1.13 (1.05–1.21)

1.07 (0.91–1.26)

Estimated apoB (g/L)

SIMV

1.01 (0.0)

0.90 (0.0)

0.87 (0.0)

0.88 (0.0)

0.90 (0.0)

0.89 (0.0)

0.86 (0.01)

ATV

1.02 (0.0)

0.69 (0.0)

0.70 (0.0)

0.72 (0.0)

0.74 (0.0)

0.73 (0.0)

0.71 (0.01)

HR

1.15 (1.09–1.21)

1.11 (1.04–1.17)

1.14 (1.08–1.21)

1.17 (1.10–1.24)

1.12 (1.05–1.20)

1.11 (1.04–1.20)

1.07 (0.91–1.25)

  1. Data are expressed as mean (SE) or HR per 1-SD (95% CI)
  2. Adjusted for age and sex
  3. ATV atorvastatin, SIMV simvastatin