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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD

Fig. 1

Rare variants discovered after sequencing of 950 Japanese males who did not abuse alcohol. Individual variations (minor allele frequencies less than 2%) are shown according to the genomic position of MTTP (a), PNPLA3 (b) and TM6SF2 (c). The number of circles on the top and bottom represents the number of times that the variant is observed in cases or controls, respectively. Open circles show synonymous variants and an intronic variant. Gray circles indicate non-synonymous variants that are predicted to be a benign substitution by PolyPhen software. Black circles indicate non-synonymous variants and splicing variants that are predicted to be damaging

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