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Table 3 Association studies of individual rare alleles with plasma lipid levels in Japanese individuals

From: Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD

Gene

dbSNP ID

Position

TG

LDL

   

b

(95% CI)

P

b

(95%CI)

P

MTTP

rs756998920

Val42Ile

−0.039

−0.198 - -0.023

0.014

−0.025

−21.7 - 3.5

0.157

MTTP

rs61750974

Val168Ile

−0.022

−0.079 - 0.014

0.167

0.011

−4.4 - 8.7

0.523

MTTP

rs760898561

Pro514Arg

0.242

−0.179 - 0.306

0.002

−0.022

−27.8 - 6.1

0.210

MTTP

rs771890416

Ser861Asn

−0.006

−0.164 - 0.113

0.242

0.007

−15.9 - 23.8

0.694

PNPLA3

rs143392071

Tyr220Cys

0.013

−0.039 - 0.097

0.401

0.020

−4.1 - 15.3

0.259

PNPLA3

rs148469440

c.697-5C > A

0.021

−0.023 - 0.121

0.182

−0.019

−15.9 - 4.7

0.288

PNPLA3

rs147289545

Arg447Gln

−0.022

−0.155 - 0.026

0.160

−0.012

−17.4 - 8.4

0.492

TM6SF2

rs142056540

Arg138Trp

0.011

−0.101 - 0.219

0.471

0.013

−14.5 - 31.3

0.473

PNPLA3

rs738409

Ile148Met

−0.025

−0.019 - 0.002

0.121

0.011

−1.0 - 2.0

0.531

TM6SF2

rs58542926

Glu167Lys

−0.054

−0.050 - -0.013

0.001

−0.027

−4.5 - 0.7

0.130

  1. Association of the individual SNP with log transformed triglyceride (TG) and LDL-cholesterol (LDL) was assessed by multiple regression model. Age, sex, visceral fat depot, HbA1c and rs58542926 were used as covariates