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Table 2 Genotype and allele frequencies of the BRCA2 rs9534275 SNP in cases and controls

From: Association between single nucleotide polymorphism rs9534275 and the risk of coronary artery disease and ischemic stroke

Genotype or allele

Control [n (%)]

CAD [n (%)]

IS [n (%)]

CAD

IS

OR (95% CI)

P

OR (95% CI)

P

TT

203 (31.4)

150 (24.8)

140 (24.6)

1

 

1

 

GT

310(47.9)

316 (52.1)

291 (51.1)

1.58 (1.19–2.08)

0.365

1.52 (1.15–2.01)

0.214

GG

134 (20.7)

140 (23.1)

138 (24.3)

1.78 (0.82–1.91)

0.005

1.85 (1.32–2.59)

0.003

X 2

 

6.812

7.257

    

P

 

0.033

0.027

    

HWE (P)

0.349

0.33

0.62

    

TT

203 (31.4)

150 (24.8)

140 (24.6)

1

 

1

 

GT/GG

444 (68.6)

456 (75.2)

429 (75.4)

1.63 (1.25–2.12)

0.004

1.61 (1.24–2.10)

0.005

X 2

 

6.783

6.854

    

P

 

0.01

0.009

    

T

716 (55.3)

616 (50.8)

571 (50.2)

1

 

1

 

G

578 (44.7)

596 (49.2)

567 (49.8)

1.35(1.14–1.60)

0.005

1.37 (1.16–1.62)

0.002

X 2

 

5.106

6.462

    

P

 

0.025

0.012

    
  1. Adjusted for sex, age, smoking, drinking, BMI, diabetes, hypertension, hyperlipidemia. CAD, coronary artery disease; IS, ischemic stroke
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Lipids in Health and Disease

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