Fig. 4From: Fenofibrate decreases the bone quality by down regulating Runx2 in high-fat-diet induced Type 2 diabetes mellitus mouse modelThe effect of high dose fenofibrate on osteoblast viability and its regulation on the expression of Runx2 gene. a Fenofibrate decreased the MC3T3 cell viability at different concentrations measured by a CCK-8 assay. The expression of b Runx2, c osteocalcin, d Spp1 and e Sp7 in MC3T3 cells after treated with different concentrations of fenofibrate was analyzed by qPCR. Data are expressed as fold changes compared to the untreated control, and were presented as mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001Back to article page