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Table 1 Main characteristics and quality of included studies

From: High-density lipoprotein cholesterol efflux capacity is inversely associated with cardiovascular risk: a systematic review and meta-analysis

Study ID Country Study type Subjects No. (Male, %) Subject characteristics Age, y Follow-up, y Donor cell line Labeled-cholesterol Cholesterol acceptor NOS
Bauer, L, 2017 [30] Germany Cohort 526 (59) CKD 65 ± 12 4.6 J774 3H–cholesterol ApoB-depleted plasma 7
Tejera–Segura, B 2017 [31] Spanish Cross-sectional 401 (26) RA 57 ± 10 / J774 BODIPY-cholesterol ApoB-depleted plasma 5
Kopecky, C, 2016 [32] German Cohort 1147 (54.8) Hemodialysis patients 66 4.1 THP-1 3H–cholesterol ApoB-depleted plasma 7
Javaheri, A, 2016 [33] USA Cohort 35 (85.7) Cardiac transplant recipients 44 ± 4 2.6 J774 3H–cholesterol ApoB-depleted plasma 6
Mody, P, 2016 [34] USA Cohort 1972 (44) Free from CVD 45 ± 9 9.4 J774 BODIPY-cholesterol ApoB-depleted plasma 8
Liu, C 2016 [35] China Cohort 1737 (65.2) CAD 64 3.8 J774 BODIPY-cholesterol ApoB-depleted plasma 6
Zhang, J 2016 [36] China Cohort 313 (75.4) CAD 66 ± 11 3 J774 3H–cholesterol ApoB-depleted plasma 6
Ogura, M, 2016 [37] Japan Cross-sectional 227 (44.5) Heterozygous FH 57 ± 17 / J774 3H–cholesterol ApoB-depleted plasma 6
Annema, W, 2016 [38] Netherlands Cohort 495 (54.5) Renal Transplant Recipients 52 ± 12 7 THP-1 3H–cholesterol ApoB-depleted plasma 8
Ishikawa, T, 2016 [39] Japan Case-control 258 (76.7) CAD VS non-CAD 66 ± 11 / J774 3H–cholesterol ApoB-depleted plasma 5
Saleheen, D, 2015 [40] UK Nested case-control 3494 (64.5) CHD vs. non-CHD 65 ± 8; 6 J774 3H–cholesterol ApoB-depleted plasma 8
Rohatgi, A, 2014 [12] Dallas Cohort 2924 (43) Free from CVD 42 9.4 J774 BODIPY-cholestero ApoB-depleted plasma 9
Li, X M, 2013 [41] USA Case-control 1150 (63.8) CAD vs. non-CAD 64 ± 11 / J774 3H–cholesterol ApoB-depleted plasma 6
Khera, A V1, 2011 [29] Caucasian Cross-sectional 793 (59.7) CAD vs. non-CAD 58 ± 10 / J774 3H–cholesterol ApoB-depleted plasma 6
Khera, A V, 2011 [29] Caucasian Cross-sectional 203 (54.2) Healthy population 51 ± 8 / J774 3H–cholesterol ApoB-depleted plasma 6
  1. Notes: NOS Newcastle-Ottawa Scale, CKD chronic kidney disease, RA rheumatoid arthritis, DM diabetes mellitus, ESR erythrocyte sedimentation rate, CVD cardiovascular disease, CAD coronary artery disease, CHD coronary heart disease events, FH familial hypercholesterolemia, ApoB apolipoprotein B