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Table 1 Main characteristics and quality of included studies

From: High-density lipoprotein cholesterol efflux capacity is inversely associated with cardiovascular risk: a systematic review and meta-analysis

Study ID

Country

Study type

Subjects No. (Male, %)

Subject characteristics

Age, y

Follow-up, y

Donor cell line

Labeled-cholesterol

Cholesterol acceptor

NOS

Bauer, L, 2017 [30]

Germany

Cohort

526 (59)

CKD

65 ± 12

4.6

J774

3H–cholesterol

ApoB-depleted plasma

7

Tejera–Segura, B 2017 [31]

Spanish

Cross-sectional

401 (26)

RA

57 ± 10

/

J774

BODIPY-cholesterol

ApoB-depleted plasma

5

Kopecky, C, 2016 [32]

German

Cohort

1147 (54.8)

Hemodialysis patients

66

4.1

THP-1

3H–cholesterol

ApoB-depleted plasma

7

Javaheri, A, 2016 [33]

USA

Cohort

35 (85.7)

Cardiac transplant recipients

44 ± 4

2.6

J774

3H–cholesterol

ApoB-depleted plasma

6

Mody, P, 2016 [34]

USA

Cohort

1972 (44)

Free from CVD

45 ± 9

9.4

J774

BODIPY-cholesterol

ApoB-depleted plasma

8

Liu, C 2016 [35]

China

Cohort

1737 (65.2)

CAD

64

3.8

J774

BODIPY-cholesterol

ApoB-depleted plasma

6

Zhang, J 2016 [36]

China

Cohort

313 (75.4)

CAD

66 ± 11

3

J774

3H–cholesterol

ApoB-depleted plasma

6

Ogura, M, 2016 [37]

Japan

Cross-sectional

227 (44.5)

Heterozygous FH

57 ± 17

/

J774

3H–cholesterol

ApoB-depleted plasma

6

Annema, W, 2016 [38]

Netherlands

Cohort

495 (54.5)

Renal Transplant Recipients

52 ± 12

7

THP-1

3H–cholesterol

ApoB-depleted plasma

8

Ishikawa, T, 2016 [39]

Japan

Case-control

258 (76.7)

CAD VS non-CAD

66 ± 11

/

J774

3H–cholesterol

ApoB-depleted plasma

5

Saleheen, D, 2015 [40]

UK

Nested case-control

3494 (64.5)

CHD vs. non-CHD

65 ± 8;

6

J774

3H–cholesterol

ApoB-depleted plasma

8

Rohatgi, A, 2014 [12]

Dallas

Cohort

2924 (43)

Free from CVD

42

9.4

J774

BODIPY-cholestero

ApoB-depleted plasma

9

Li, X M, 2013 [41]

USA

Case-control

1150 (63.8)

CAD vs. non-CAD

64 ± 11

/

J774

3H–cholesterol

ApoB-depleted plasma

6

Khera, A V1, 2011 [29]

Caucasian

Cross-sectional

793 (59.7)

CAD vs. non-CAD

58 ± 10

/

J774

3H–cholesterol

ApoB-depleted plasma

6

Khera, A V, 2011 [29]

Caucasian

Cross-sectional

203 (54.2)

Healthy population

51 ± 8

/

J774

3H–cholesterol

ApoB-depleted plasma

6

  1. Notes: NOS Newcastle-Ottawa Scale, CKD chronic kidney disease, RA rheumatoid arthritis, DM diabetes mellitus, ESR erythrocyte sedimentation rate, CVD cardiovascular disease, CAD coronary artery disease, CHD coronary heart disease events, FH familial hypercholesterolemia, ApoB apolipoprotein B