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Table 2 Effect of ALA/LA on SOD, GSH-PX, CAT and NADPH-PX level of HK-2 cell induced with high glucose (\( \overline{x} \) ±s)

From: ALA/LA ameliorates glucose toxicity on HK-2 cells by attenuating oxidative stress and apoptosis through the ROS/p38/TGF-β1 pathway

group

dose (μM)

SOD (mM)

GSH-PX (mM)

CAT (mM)

NADPH-PX(mM)

N

0

185.66 ± 15.90*

207.40 ± 18.29*

6.61 ± 0.60*

37.30 ± 3.66*

G

0

83.64 ± 8.50#

73.86 ± 18.39#

3.59 ± 0.54#

86.52 ± 3.20#

A1

10

286.00 ± 19.53**

87.29 ± 10.23

6.39 ± 0.73*

63.85 ± 1.97*

A2

50

304.50 ± 8.46**

107.43 ± 22.04

6.21 ± 0.86*

56.13 ± 3.79*

A3

100

252.24 ± 16.73*

161.79 ± 30.77*

3.28 ± 0.36

54.08 ± 4.04*

A4

200

229.97 ± 44.72*

59.42 ± 12.98

2.25 ± 0.40

68.01 ± 3.11*

L1

10

215.54 ± 11.98*

73.99 ± 18.71

6.41 ± 0.49*

46.62 ± 0.98*

L2

50

189.76 ± 26.83*

185.27 ± 21.02*

4.17 ± 0.53

43.92 ± 2.82*

L3

100

155.28 ± 32.11

209.33 ± 23.30*

2.27 ± 0.72

48.01 ± 2.39*

L4

200

155.59 ± 13.68

107.46 ± 25.81

4.32 ± 0.43

54.28 ± 4.30*

E1

10

262.93 ± 34.99*

96.16 ± 16.33

3.57 ± 0.51

80.56 ± 3.3

E2

50

252.33 ± 6.56*

50.17 ± 11.58

3.68 ± 0.62

71.22 ± 2.82*

E3

100

261.65 ± 6.14*

107.61 ± 22.73

7.61 ± 1.93*

76.17 ± 2.80*

E4

200

247.74 ± 11.99*

53.72 ± 12.08

2.13 ± 0.38

82.66 ± 3.22

M1

50 (1:1)

249.80 ± 13.62*

107.61 ± 22.73

12.66 ± 2.34*

82.91 ± 3.95

M2

50 (1:4)

256.60 ± 21.92*

201.73 ± 24.21

5.76 ± 0.77

74.51 ± 2.32*

M3

50 (1:8)

246.53 ± 45.78*

59.71 ± 12.28

3.65 ± 0.67

80.77 ± 2.24

M4

100 (1:1)

273.29 ± 15.59*

178.99 ± 40.81*

6.30 ± 0.96*

63.38 ± 4.25*

M5

100 (1:4)

221.32 ± 26.12*

230.95 ± 44.38*

3.32 ± 1.47

42.78 ± 1.27*

M6

100 (1:8)

240.02 ± 41.92*

135.41 ± 27.25

3.13 ± 0.81

63.39 ± 2.47*

  1. Data are presented as mean ± SEM. # P < 0.05 vs. control group. * P < 0.05, ** P < 0.01 vs. model group. N: normal control group; G: high glucose model group; A1-A4: ALA group at dose of 10, 50, 100, 200 μM; L1-L4:LA group at dose of 10, 50, 100, 200 μM; E1-E4 EPA group at dose of 10, 50, 100, 200 μM, M1-M3: mixture of ALA and LA group at dose of 50 μM with ALA/LA ratio of 1:1, 1:4, 1:8; M4-M6: mixture of ALA and LA group at dose of 100 μM with ALA/LA ratio of 1:1, 1:4, 1:8