EPHA6 rs4857055 C > T polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population

Kim, Minjoo; Yoo, Hye Jin; Kim, Minkyung; Kim, Jiyoo; Baek, Seung Han; Song, Min; Lee, Jong Ho

doi:10.1186/s12944-017-0620-5

Lipids in Health and Disease

Table 3 Clinical and biochemical characteristics in normotensive controls and subgroups of hypertension patients according to EPHA6 genotype

From: EPHA6 rs4857055 C > T polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population

EPHA6	Normotensive controls (n = 1605)			Hypertension group (n = 541)
EPHA6	CC (n = 446)	CT allele (n = 829)	TT (n = 330)	CC (n = 135)	CT allele (n = 261)	TT (n = 145)
Age (year)	47.9 ± 10.9	48.4 ± 10.8	47.4 ± 11.3	54.6 ± 11.1	54.8 ± 11.8	53.1 ± 11.8
Weight (kg)	63.4 ± 9.98	62.7 ± 10.3	63.4 ± 10.6	66.8 ± 11.3	68.7 ± 12.2	68.1 ± 11.7
BMI (kg/m²)	23.8 ± 2.89	23.7 ± 2.94	23.8 ± 2.87	25.0 ± 3.21	25.5 ± 3.23	25.5 ± 3.14
Waist (cm)	83.6 ± 7.75	83.4 ± 7.84	83.6 ± 7.71	87.0 ± 8.76	88.1 ± 8.79	88.1 ± 8.48
Waist hip ratio	0.88 ± 0.06	0.88 ± 0.06	0.89 ± 0.06	0.90 ± 0.06	0.90 ± 0.05	0.91 ± 0.07
Systolic BP (mmHg)	114.5 ± 11.5^b	117.0 ± 11.5^a	117.4 ± 11.2^a	136.4 ± 15.9^b	138.0 ± 14.6^a,b	141.3 ± 15.9^a
Diastolic BP (mmHg)	71.7 ± 8.67^b	73.0 ± 8.63^a	73.1 ± 8.95^a,b	86.5 ± 11.0	87.2 ± 10.6	88.7 ± 10.3
Triglyceride (mg/dL)^∮	115.4 ± 64.3	122.3 ± 77.8	119.1 ± 75.9	144.5 ± 79.5^a,b	141.2 ± 78.7^b	165.0 ± 106.2^a
Total cholesterol (mg/dL)^∮	200.0 ± 37.3	197.2 ± 36.2	197.4 ± 33.8	196.0 ± 33.7	198.5 ± 38.5	200.0 ± 33.2
HDL cholesterol (mg/dL)^∮	54.2 ± 12.8	53.7 ± 13.9	54.0 ± 13.6	51.0 ± 12.8	50.8 ± 13.4	49.1 ± 11.7
LDL cholesterol (mg/dL)^∮	122.9 ± 33.3	120.1 ± 33.1	120.7 ± 30.6	116.2 ± 29.2	120.1 ± 35.3	120.1 ± 31.0
Apolipoprotein A-I (mg/dL)^∮	157.3 ± 26.3	155.9 ± 29.6	155.0 ± 27.1	154.1 ± 25.6	155.8 ± 30.2	156.1 ± 25.6
Apolipoprotein B (mg/dL)^∮	107.6 ± 29.3	103.3 ± 29.4	102.9 ± 28.6	100.8 ± 27.2^b	103.2 ± 28.6^b	110.6 ± 25.9^a
Glucose (mg/dL)^∮	95.0 ± 20.1	95.7 ± 19.7	96.4 ± 23.7	104.4 ± 23.9	104.0 ± 27.6	103.5 ± 24.5
Insulin (μIU/dL)^∮	9.32 ± 4.91	8.97 ± 4.64	9.04 ± 4.32	8.99 ± 4.33	10.1 ± 6.39	10.2 ± 5.67
HOMA-IR^∮	2.18 ± 1.24	2.13 ± 1.35	2.15 ± 1.17	2.30 ± 1.32	2.63 ± 2.42	2.63 ± 1.77
LDL particle size (nm)^∮	24.0 ± 0.81	23.9 ± 1.27	24.0 ± 0.77	24.0 ± 0.94^b	24.0 ± 0.66^b	23.5 ± 0.85^a

Mean ± SD. ^∮tested by logarithmic transformation. P-values derived from a One-way ANOVA. All alphabetical P < 0.05 derived from Bonferroni post hoc tests; no significant differences are marked with the same alphabet and significant differences are marked with a different alphabet

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