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Table 4 Erythrocytes fatty acid profiles of the study population determined by gas chromatography

From: Role of disturbed fatty acids metabolism in the pathophysiology of diabetic erectile dysfunction

Fatty Acids

(nomenclature)

Name

Patients with VED (%) (n = 72)

Patients w/o VED (%) (n = 78)

Controls (%)

(n = 88)

C12: 0

Lauric acid

0.21 ± 0.12

0.19 ± 0.11

0.21 ± 0.13

C13: 0

Tridecylic acid

0.79 ± 0.53**

0.47 ± 0.45

0.53 ± 0.35

C14: 0

Myristic acid

4.12 ± 2.50***

3.03 ± 2.09*

2.57 ± 2.30

C15: 0

Pentadecylic acid

1.07 ± 0.69***

0.75 ± 0.45*

0.63 ± 0.51

C16: 0

Palmitic acid

28.82 ± 5.75**

29. 25 ± 6.66**

25.87 ± 4.16

C18: 0

Stearic acid

11.93 ± 5.82***

13.29 ± 5.18*

14.88 ± 5.15

C20: 0

Arachidic acid

0.24 ± 0.32

0.23 ± 0.13*

0.26 ± 0.31

C22: 0

Behenic acid

0.43 ± 0.41***

0.35 ± 0.16**

0.27 ± 0.21

C23: 0

Tricosylic acid

0.59 ± 0.42

0.44 ± 0.28

0.60 ± 0.79

C24: 0

Lignoceric acid

2.06 ± 0.83**

1.75 ± 1.14

1.42 ± 1.19

C26: 0

Cerotic acid

5.47 ± 2.28***

3.21 ± 3.05**

3.72 ± 2.81

Σ SFA

 

55.70 ± 9.4**

52.84 ± 7.1

51,01 ± 8.7

C14:1 cis-9 (n-5)

Myristoleic acid

1.33 ± 0.71**

0.98 ± 0.44***

1.60 ± 0.56

C16:1 cis-9 (n-7)

Palmitoleic acid

0.56 ± 0.51

0.60 ± 0.54

0.57 ± 0.47

C18:1 cis-9 (n-9)

Oleic acid

10.96 ± 4.18***

13.14 ± 3.31*

14.53 ± 3.65

C18:1 cis 11(n-7)

Vaccenic acid

1.31 ± 0.30

1.39 ± 0.38

1.47 ± 0.49

C20:1 cis11 (n-9)

Eicosenoic acid

0.16 ± 0.13***

0.22 ± 0.18*

0.26 ± 0.17

C22:1 cis13(n-9)

Erucic acid

0.45 ± 0.21

0.50 ± 0.21

0.54 ± 0.87

C24:1 (n-9)

Nervonic acid

1.70 ± 0.59***

1.61 ± 0.97***

3.00 ± 1.31

Σ MUFA

 

16.50 ± 4.12***

18.43 ± 3.65***

21.00 ± 3.88

Omega 3 family (n-3)

 C18:3 cis9,12,15

α-linolenic acid

0.66 ± 0.34***

0.63 ± 0.27***

0.51 ± 0.28

 C20:3 cis11,14,17

Eicosatrienoic acid

1.43 ± 0.48

1.80 ± 0.83*

1.61 ± 0.95

 C20:5 EPA

Eicosapentaenoic acid

0.52 ± 0.26***

1.26 ± 1.02

1.54 ± 1.92

 C22:6 DHA

Docosahexaenoic acid

2.00 ± 1.39***

2.27 ± 1,21***

3.13 ± 1.20

Omega 6 family (n-6)

 C18:2 cis9,12

Linoleic acid

12.05 ± 4.46***

10.40 ± 3.20**

9.40 ± 5.21

 C18:3 cis6,9,12

γ-linolenic acid

0.16 ± 0.17*

0.19 ± 0.14

0.17 ± 0.11

 C20:3 cis8,11,14

Dihomo-γlinolenic acid

0.18 ± 0.09***

0.28 ± 0.16

0.38 ± 0.27

 C20:4

Arachidonic acid

10.75 ± 3.09*

11.43 ± 2.38***

9.25 ± 3.36

 Σ PUFA

 

27.79 ± 5.06

28.42 ± 4.11

26.03 ± 5.85

 Σ UFA

 

44.30 ± 5.75**

47.16 ± 6.03

47.03 ± 6.75

Desaturation index

 C20:4/C20:3 (Δ5D)

 

77.03 ± 51.26***

54.18 ± 40.75*

47.99 ± 43.92

 C18:3/C18:2n-6 (Δ6D)

 

0.015 ± 0.016**

0.020 ± 0.015

0.023 ± 0.021

 C16:1/C16:0 (Δ9D-16)

 

0.02 ± 0.02

0.02 ± 0.02

0.02 ± 0.01

 C18:1/C18:0 (Δ9D-18)

 

1.18 ± 0.87

1.17 ± 0.66

1.17 ± 0.71

 C24:1/C18:1

 

0.18 ± 0.11*

0.12 ± 0.08***

0.22 ± 0.12

 C18:0/C16:0

 

0.41 ± 0.21***

0.48 ± 0.21**

0.57 ± 0.17

  1. Data obtained by GC are expressed as relative values (%): mean % of total FAs ± SD; Σ SFA, sum of saturated fatty acids; Σ MUFA, sum of monounsaturated fatty acids; Σ PUFA, sum of polyunsaturated fatty acids; Σ UFA, sum of unsaturated fatty acids; C20:4/C20:3, Δ5 desaturation index; C18:3/C18:2, Δ6 desaturation index; C16:1/C16:0 and C18:1/C18:0, Δ9 desaturation index; C24:1/C18:1 and C18:0/C16:0, elongation index; w/o, without
  2. *P < 0.05; **P < 0.01 and ***P < 0.001 compared to controls. The Mann-Whitney test with Bonferroni correction was used