Table 1 Top Canonical pathways identified in adipose tissue of rats undergoing two cycles of chemotherapy
Pathway | P-value | Ratio | Molecules |
|---|---|---|---|
Mitochondrial Dysfunction | 5.01E-14 | 0.1 | SDHB, NDUFA9, ATP5O, MT-CO2, PDHA1, PRDX3, PARK7, NDUFV2, UQCRC2,CAT, COX5A, UQCRFS1, VDAC1,UQCRC1, MAOA, GPX3, GSTMS |
Gluconeogenesis | 7.94E-13 | 0.3 | ENO1, ENO3, PGAM1, ALDOA, GAPDH, ME1, MDH2, ALDOC |
Glycolysis | 4.90E-09 | 0.2 | ENO1, ENO3, PGAM1, ALDOA, GAPDH, ALDOC |
Oxidative Phosphorylation | 1.26E-08 | 0.1 | SDHB, NDUFA9, NDUFV2, UQCRC2, ATP5O, COX5A, UQCRFS1, MT-CO2, UQCRC1 |
Krebs Cycle | 1.74E-07 | 0.2 | SDHB, CS, IDH3A, IDH2, FH, MDH2 |
Acetyl-CoA Biosynthesis (Pyruvate Dehydrogenase Complex) | 6.31E-06 | 0.4 | PDHA1, DLAT, PDHB |
TR/RXR Activation | 2.09E-05 | 0.1 | ENO1, FAS, ACACA, PCK1, ME1, THRSP |
Pentose Phosphate Pathway | 2.09E-05 | 0.3 | PGD, TKT, PGLS |
Fatty Acid β-oxidation | 3.24E-05 | 0.1 | ECHS1, ACAA1, SCP2, IVD, CPT2, ACADVL |