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Table 1 Top Canonical pathways identified in adipose tissue of rats undergoing two cycles of chemotherapy

From: Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer

Pathway P-value Ratio Molecules
Mitochondrial Dysfunction 5.01E-14 0.1 SDHB, NDUFA9, ATP5O, MT-CO2, PDHA1, PRDX3, PARK7, NDUFV2, UQCRC2,CAT, COX5A, UQCRFS1, VDAC1,UQCRC1, MAOA, GPX3, GSTMS
Gluconeogenesis 7.94E-13 0.3 ENO1, ENO3, PGAM1, ALDOA, GAPDH, ME1,
Glycolysis 4.90E-09 0.2 ENO1, ENO3, PGAM1, ALDOA, GAPDH, ALDOC
Oxidative Phosphorylation 1.26E-08 0.1 SDHB, NDUFA9, NDUFV2, UQCRC2, ATP5O, COX5A, UQCRFS1, MT-CO2, UQCRC1
Krebs Cycle 1.74E-07 0.2 SDHB, CS, IDH3A, IDH2, FH, MDH2
Acetyl-CoA Biosynthesis (Pyruvate Dehydrogenase Complex) 6.31E-06 0.4 PDHA1, DLAT, PDHB
TR/RXR Activation 2.09E-05 0.1 ENO1, FAS, ACACA, PCK1, ME1, THRSP
Pentose Phosphate Pathway 2.09E-05 0.3 PGD, TKT, PGLS
Fatty Acid
3.24E-05 0.1 ECHS1, ACAA1, SCP2, IVD, CPT2, ACADVL
  1. The ratio is calculated based on the numbers of proteins in a given pathway divided by total numbers of proteins that make up that pathway in IPA. P-value calculated by Fisher’s exact test. Abbreviations: TR Thyroid hormone receptor, RXR Retinoid X receptor, LXR Liver X receptor