Upstream regulator | Molecular type | Predicted activation state | Activation Z-score* | P-value of overlap | Target molecules in differentially expressed dataset |
---|---|---|---|---|---|
PPARGC1A | Transcription regulator | Inhibited | −4.379 | 2.17E-19 | ACACA, ACADVL, ACAT1, ATP5O, CAT, COX5A, CS,DLAT, FASN, IDH3A, MDH2, ME1, MT-CO2, NDUFV2, PCK1, PDHA1, PGAM1, PRDX3, SLC2A4,UQCRFS1 |
PPARγ | Ligand-dependent nuclear receptor | Inhibited | −4.06 | 1.629E-23 | ACAA1, ACACA, ACLY, ATP5O, CAT, CPT2, CS, DLAT, FABP1, FASN, FDPS, GAPDH, GPD1,GPT, IDH1, IVD, KRT18, LIPE, ME1, MGLL, PC, PCK1, PDHB, PYGL, RPSA, SCP2, Slc25a1, SLC2, TKT |
PPARα | Ligand-dependent nuclear receptor | Inhibited | −2.97 | 4.41E-16 | ACAA1, ACACA, ACADVL, ACAT1, ACAT2, CAT, CPT2, CS, DBI, FABP1, FASN, FDPS, GPD1, GPT, MGLL,MT-CO2, PC, PCK1, PRDX6, SCP2, SLC2A4, UQCRC1 |
MYC | Transcription regulator | Inhibited | −2.61 | 2.27E-12 | ACACA, ACAT1, AK2, ALDOA, CANX, CAPNS1, CPT2, DBI, ENO1, FABP1, FASN, GAPDH, GCSH, GPT, HSPE1, IDH1, IDH2, LUM, NDRG2, PCK1, PDHA1, PGAM1, PHB, PHB2, PRDX3, SLC25A5, TKT |
SREBF1 | Transcription regulator | Inhibited | −2.13 | 7.82E-09 | ACACA, ACLY, ALDOC, DBI, FASN, FDPS, GPX3, IDH1, PCK1, THRSP, UQCRFS1 |
MAP4K4 | Kinase | Activated | 3.44 | 8.13 E-13 | ACACA, ACADVL, ACLY, DLAT, FASN, IVD, MGLL, PGAM1, SCP2, SLC2A4, UQCRC1, UQCRFS1 |
5-Fluorouracil | Chemical drug | Activated | 3.21 | 1.30E-11 | ALDOA, ATP5O, CANX, CAPNS1, ECHS1, FDPS, GAPDH, HSPE1, IDH2, NDUFV2, PSMA7, RPS8, SLC25A5, UQCRC2 |