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Table 4 Fatty acid composition of phospholipids in periuterine adipose tissue of Fischer 344 rats

From: Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer

Fatty acids (% total) REF TUM 1- Cycle 2-Cycles
C16:0 26.4 ± 1.4a 26.2 ± 2a 28.8 ± 1.3a 29.4 ± 1.4a
C16:1 3.0 ± 0.1a 1.6 ± 0.2b 1.4 ± 0.1 b 1.5 ± 0.2b
C18:0 22.3 ± 0.6a 30.3 ± 1.1b 29.2 ± 1.1b 30.1 ± 1.4b
C18:1 26.3 ± 1.4a 17.0 ± 1.5b 16.9 ± 1.5b 16.1 ± 1.2b
C18:2n6 13.4 ± 0.6a 12.4 ± 0.8a 12.2 ± 0.8a 11.6 ± 0.6a
C18:3n3 0.8 ± 0 a 0.2 ± 0b 0.2 ± 0.1b 0.2 ± 0b
C20:4n6 5.4 ± 0.6a 8.3 ± 0.7a 7.6 ± 0.5a 7.03 ± 0.5a
C20:5n3 0.1 ± 0a NDa NDa NDa
C22:6n3 0.8 ± 0.1a 0.5 ± 0ab 0.3 ± 0b 0.3 ± 0b
ΣSFA 49.9 ± 1a 57.9 ± 2.3b 59.2 ± 1.8b 61 ± 1.9b
ΣMUFA 29.4 ± 1.3a 19.2 ± 1.6b 19.2 ± 1.6b 18.3 ± 1.4b
Σn-6/n-3 11.1 ± 0.5a 16.1 ± 0.5ab 21.0 ± 1.6b 18.6 ± 1.2b
Σn-6 18.9 ± 0.6a 21.5 ± 1.1a 20.6 ± 0.8a 19.5 ± 0.8a
Σn-3 1.7 ± 0.1a 1.3 ± 0.1ab 1.0 ± 0.1b 1.1 ± 0.1b
  1. Phospholipid fatty acids in periuterine adipose tissue of Fischer 344 rats bearing the Ward colorectal carcinoma receiving 1- or 2- cycles of chemotherapy. Healthy rats were used a reference for comparison (REF). Mean ± SEM, Kruskall test was used to determine significant differences between groups. Different superscripts (a, b) indicate significant differences between groups (P < 0.05); (n = 6–8/group). Abbreviations: SFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids; REF, Healthy, TUM Tumour-bearing, ND not determined