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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

Fig. 1

The effect of mevalonate (column B), FPP (column C), and GGPP (column D) on statin-mediated GFP-K-Ras protein translocation in the human pancreatic cancer cells. MiaPaCa-2 human pancreatic cancer cells expressing GFP-K-Ras were treated with statins (20 μM) together with mevalonate (600 μM), FPP (17 μM) or GGPP (17 μM), respectively, for 24 h. MiaPaCa-2 cells treated only with statins (column A) were used as the control of the statins’ effect on GFP-K-Ras protein localization. Simva = simvastatin; FPP = farnesyl pyrophosphate; GGPP = geranylgeranyl pyrophosphate

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