Table 2 Signaling and metabolic pathways enriched by genes that change expression intensity after simvastatin, FPP, and GGPP treatment of MiaPaCa-2 human pancreatic cancer cells
KEGG Path ID | Path name | Simva | FPP | Simva + FPP | GGPP | Simva + GGPP |
|---|---|---|---|---|---|---|
hsa03030 | DNA replication | + | + | + | – | + |
hsa04110 | Cell cycle | + | + | + | – | + |
hsa03430 | Mismatch repair | + | + | – | – | – |
hsa00100 | Steroid biosynthesis | + | – | – | – | – |
hsa03440 | Homologous recombination | + | – | – | – | – |
hsa04010 | MAPK signaling pathway | + | – | – | – | – |
hsa00240 | Pyrimidine metabolism | + | – | – | – | – |
hsa00190 | Oxidative phosphorylation | (−) | + | + | – | + |