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Table 2 Signaling and metabolic pathways enriched by genes that change expression intensity after simvastatin, FPP, and GGPP treatment of MiaPaCa-2 human pancreatic cancer cells

From: Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

KEGG Path ID Path name Simva FPP Simva + FPP GGPP Simva + GGPP
hsa03030 DNA replication + + + +
hsa04110 Cell cycle + + + +
hsa03430 Mismatch repair + +
hsa00100 Steroid biosynthesis +
hsa03440 Homologous recombination +
hsa04010 MAPK signaling pathway +
hsa00240 Pyrimidine metabolism +
hsa00190 Oxidative phosphorylation (−) + + +
  1. Gene set enrichment analysis (GSEA) performed on KEGG signaling and metabolic pathways reveals the pathways enriched for genes that are differentially transcribed after simvastatin (12 μM) treatment, and the modulatory effects of FPP (17 μM) and GGPP (17 μM)
  2. + GSEA FDR < 0.001; − GSEA FDR > 0.001; (−) oxidative phosphorylation was only marginally significant in GSEA analysis by Tian with FDR < 0.05
  3. Simva simvastatin, FPP farnesyl pyrophosphate, GGPP geranylgeranyl pyrophosphate, FDR false discovery rate