Protective effects of Mentha piperita L. leaf essential oil against CCl4 induced hepatic oxidative damage and renal failure in rats

Table 3 Effects of CCl₄, MpEO and their combination MpEO/CCl₄ on hepatic markers in serum of control and experimental rats

Treatment and parameters	AST (U/L)	ALT (U/L)	ALP (U/L)	LDH (U/L)	γ-GT (U/L)
Control	164.82 ± 1.28	65.88 ± 1.44	149.61 ± 2.19	20.81 ± 0.52	3.17 ± 0.39
CCl₄	524.12 ± 5.11^***	179.23 ± 3.39^***	217.47 ± 8.55^***	40.66 ± 0.81^***	5.43 ± 0.21^***
SL/CCl₄	191.15 ± 2.14^###	87.82 ± 7.61^###	157.50 ± 5.12^##	28.62 ± 0.62^###	3.47 ± 0.06^###
MpEO^a/CCl₄	479.89 ± 36.41	162.02 ± 9.18	202.42 ± 7.62	37.75 ± 1.35	4.45 ± 0.25
MpEO^b/CCl₄	356.82 ± 35.77^##	147.35 ± 5.67^##	186.74 ± 3.98^#	34.16 ± 1.35^##	4.06 ± 0.17^##
MpEO^c/CCl₄	216.80 ± 7.26^###	97.82 ± 6.98^###	165.96 ± 5.12^###	31.64 ± 5.12^###	3.51 ± 0.20^###
MpEO^c	160.80 ± 2.47	63.08 ± 1.16	139.77 ± 7.27	19.89 ± 0.18	2.81 ± 0.24

AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, LDH lacatate dehydrogenase and γGT gamma glutamyl transferase.^aMpEO(5 mg/kg BW), ^bMpEO(15 mg/kg BW), ^cMpEO(40 mg/kg BW), SL: Silymarin (50 mg/kg BW)
Values are mean ± SEM for eight rats in each group. CCl₄, MpEO and MpEO/CCl₄ treated groups vs control group; ** p < 0.01, *** p < 0.001, CCl₄ group vs MpEO/CCl₄ group; ^# p < 0.05, ^{# #} p < 0.01, ^{# # #} p < 0.001

ISSN: 1476-511X