Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls

Li, Yan; Chen, Zhen; Song, Hejian

doi:10.1186/s12944-017-0651-y

Lipids in Health and Disease

Table 1 Characteristics of all studies included in this meta-analysis

From: Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls

Author	Year	Country	Ethnicity	Control source	Case	Control	Case			Control			P _HWE
Author	Year	Country	Ethnicity	Control source	Case	Control	AA	AG	GG	AA	AG	GG	P _HWE
Berglund et al.	1993	Sweden	Caucasian	PB	86	99	35	38	13	33	54	12	Yes
Vartiainen et al.	2000	Finland	Caucasian	PB	167	172	64	81	22	73	76	23	Yes
Senti et al.	2001	Spain	Caucasian	PB	312	317	134	139	39	141	137	39	Yes
Yusuf et al.	2004	Several	Asian	PB	1092	1187	351	498	243	389	531	267	Yes
Low et al.	2005	USA	Caucasian	HB	204	260	89	86	29	114	111	35	Yes
Helgadottir et al.¹	2007	USA	Caucasian	PB	875	447	370	399	106	174	221	52	Yes
Helgadottir et al.²	2007	USA	Caucasian	PB	933	468	359	441	133	194	213	61	Yes
Samani et al.¹	2007	Germany	Caucasian	PB	1126	1277	447	529	150	522	593	162	Yes
Samani et al.²	2007	Germany	Caucasian	PB	722	1643	293	328	101	662	753	228	Yes
Meng et al.	2008	Ireland	Caucasian	FB	482	622	203	226	53	261	292	69	Yes
Meiner et al.	2008	USA	Caucasian	PB	505	559	187	228	90	216	260	83	Yes
Serre et al.	2008	Several	Mixed	PB	789	859	335	337	117	354	402	103	Yes
Morgan et al.	2008	USA	Caucasian	HB	807	637	322	377	108	256	304	77	Yes
Assimes et al.	2008	USA	Caucasian	PB	505	514	162	187	83	144	183	130	Yes
Vennemann et al.	2008	Germany	Caucasian	PB	793	1121	311	379	103	430	528	163	Yes
Sutton et al.	2008	USA	Caucasian	FB	1575	970	545	570	183	297	347	86	Yes
Martinelli et al.	2008	Italy	Caucasian	PB	1106	383	437	501	168	145	191	47	Yes
Iakoubova et al.	2008	Scottland	Caucasian	PB	481	1080	104	137	35	256	204	59	Yes
Stewart et al.	2009	Canada	Caucasian	HB	1540	1455	183	695	662	205	616	634	Yes
Luke et al.	2009	Austria	Caucasian	HB	505	782	73	254	178	102	373	307	Yes
Bare et al.	2010	Costa Rican	Caucasian	PB	1987	2147	785	952	250	896	966	285	Yes
Assimes et al.¹	2010	U.S.A	Mixed	PB	505	514	192	220	93	161	213	140	Yes
Assimes et al.²	2010	Germany	Caucasian	HB	793	1121	311	379	103	430	528	163	Yes
Assimes et al.³	2010	U.S.A	Mixed	HB	1575	970	561	670	344	306	433	231	Yes
Assimes et al.⁴	2010	Iceland	Caucasian	PB	4313	24,952	2131	1779	403	11,813	10,689	2450	Yes
Assimes et al.⁵	2010	Finland	Caucasian	PB	167	172	64	81	22	73	76	23	Yes
Assimes et al.⁶	2010	U.S.A	Mixed	FB	378	2652	108	182	88	679	1105	868	Yes
Assimes et al.⁷	2010	Germany	Caucasian	PB	722	1643	293	328	101	662	753	228	Yes
Assimes et al.⁸	2010	Germany	Caucasian	HB	1126	1277	447	529	150	522	593	162	Yes
Assimes et al.⁹	2010	U.S.A	Caucasian	CB	505	559	187	228	90	216	260	83	Yes
Assimes et al.¹⁰	2010	Mixed	Caucasian	H-CB	789	859	335	337	117	354	402	103	Yes
Assimes et al.¹¹	2010	Mixed	Asian	H-CB	1092	1187	351	498	243	389	531	267	Yes
Assimes et al.¹²	2010	Ireland	Caucasian	FB	482	622	203	226	53	261	292	69	Yes
Assimes et al.¹³	2010	Sweden	Caucasian	PB	86	99	35	38	13	33	54	12	Yes
Assimes et al.¹⁴	2010	U.S.A	Caucasian	HB	875	447	370	399	103	174	221	52	Yes
Assimes et al.¹⁵	2010	U.S.A	Caucasian	HB	204	260	89	86	29	114	111	35	Yes
Assimes et al.¹⁶	2010	U.S.A	Caucasian	HB	807	637	322	377	108	256	304	77	Yes
Assimes et al.¹⁷	2010	U.S.A	Caucasian	HB	933	468	359	441	133	194	213	61	Yes
Assimes et al.¹⁸	2010	Spain	Caucasian	CB	312	317	134	139	39	141	137	39	Yes
Assimes et al.¹⁹	2010	Italy	Caucasian	HB	1106	383	437	501	168	145	191	47	Yes
Assimes et al.²⁰	2010	U.K.	Caucasian	CB	1922	2933	792	890	240	1242	1299	392	Yes
Bhanushali et al.	2011	India	Asian	HB	227	150	70	111	46	33	80	37	Yes
Peng et al.	2012	China	Asian	HB	289	522	69	149	71	139	262	121	Yes
Wu et al.¹	2012	China	Asian	HB	356	568	104	164	88	168	268	132	Yes
Wu et al.²	2012	China	Asian	HB	114	568	16	68	30	168	268	132	Yes
Wu et al.	2014	China	Asian	HB	288	346	74	141	73	101	166	79	Yes
Hamidizadeh et al.	2015	Iran	Caucasian	HB	100	100	35	48	17	63	27	10	No
Vishnuprabu et al.	2015	India	Asian	HB	510	532	107	252	151	121	251	160	Yes
Hubacek et al.	2016	Czech	Caucasian	HB	1889	1191	691	856	302	440	543	195	Yes
Vatte et al.	2016	Saudi Arabia	Asian	HB	1002	984	277	513	212	286	464	234	Yes

1–20: represents different studies in one publication; HB hospital based study, PB population based study, FB family based study, CB community based study, H-CB hospital and community based study, HWE Hardy-Weinberg equilibrium. Mix: the original studies didn’t clarify the race of the subjects or mixed races

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