Table 3 Identification of potential serum lipidomic biomarkers in migraine patients
From: Lipidomic analysis of serum samples from migraine patients
No. | Metabolites | Ion adduct | Retention time(min) | Experimental Mass,M/z | Fold change (Migraine/Control) | p value |
|---|---|---|---|---|---|---|
Acylcarnitine (positive ion) | ||||||
1 | Acylcarnitine15:3 | [M]+ | 2.22 | 380.2813 | 3.839↑ | 0.005 |
2 | Acylcarnitine 21:4 | [M]+ | 3.37 | 462.3571 | 3.520↑ | 0.000 |
3 | Acylcarnitine 11:1 | [M]+ | 1.95 | 328.248 | 2.094↑ | 0.004 |
4 | Acylcarnitine 14:3 | [M]+ | 2.01 | 366.2634 | 0.478↓ | 0.007 |
5 | Acylcarnitine 10:1 | [M]+ | 1.9 | 314.2327 | 0.465↓ | 0.001 |
6 | Acylcarnitine 24:0 | [M]+ | 9.93 | 512.4677 | 0.435↓ | 0.009 |
7 | Acylcarnitine 10:0 | [M]+ | 1.95 | 316.2485 | 0.402↓ | 0.002 |
8 | Acylcarnitine 26:0 | [M]+ | 12.49 | 540.498 | 0.377↓ | 0.000 |
9 | Acylcarnitine 20:0 | [M]+ | 6.09 | 456.4047 | 0.348↓ | 0.000 |
Cer_NS (positive ion) | ||||||
10 | Cer_NS 34:1; Cer_NS(d18:1/16:0) | [M + H]+ | 14.75 | 538.5197 | 3.520↑ | 0.000 |
11 | Cer_NS 36:3; Cer_NS(d18:2/18:1) | [M + H]+ | 13.19 | 562.5194 | 2.723↑ | 0.000 |
12 | Cer_NS 36:2; Cer_NS(d18:2/18:0) | [M + H]+ | 14.86 | 564.5356 | 2.430↑ | 0.000 |
lysoPC (positive ion) | ||||||
13 | lysoPC 20:0; PC(20:0/0:0) | [M + H]+ | 5.11 | 552.4031 | 2.860↑ | 0.000 |
14 | lysoPC 22:5; PC(22:5(4Z,7Z,10Z,13Z,16Z)/0:0) | [M + H]+ | 3.06 | 570.3521 | 0.474↓ | 0.002 |
15 | lysoPC 22:0; PC(22:0/0:0) | [M + H]+ | 8.07 | 580.4342 | 0.452↓ | 0.012 |
16 | lysoPC 18:2; PC(18:2(6Z,9Z)/0:0) | [M + H]+ | 3.09 | 520.3403 | 0.430↓ | 0.019 |
17 | lysoPC 15:0; PC(15:0/0:0) | [M + H]+ | 3.14 | 482.3243 | 0.423↓ | 0.000 |
18 | lysoPC 14:0; PC(14:0/0:0) | [M + H]+ | 2.89 | 468.309 | 0.393↓ | 0.000 |
19 | lysoPC 24:0; PC(24:0/0:0) | [M + H]+ | 10.33 | 608.475 | 0.337↓ | 0.000 |
20 | lysoPC 16:0; PC(16:0/0:0) | [M + H]+ | 5.22 | 496.3397 | 0.244↓ | 0.001 |
lysoPE (positive ion) | ||||||
21 | lysoPE 18:2; PE(18:2(6Z,9Z)/0:0) | [M + H]+ | 3.23 | 478.2933 | 0.466↓ | 0.015 |
22 | lysoPE 18:1; PE(18:1(17Z)/0:0) | [M + H]+ | 3.98 | 480.3085 | 0.461↓ | 0.023 |
23 | lysoPE 22:5; PE(22:5(4Z,7Z,10Z,13Z,16Z)/0:0) | [M + H]+ | 3.05 | 528.2969 | 0.411↓ | 0.007 |
24 | lysoPE 24:0; PE(24:0/0:0) | [M + H]+ | 10.62 | 566.4199 | 0.349↓ | 0.016 |
lysoPE (negative ion) | ||||||
25 | lysoPE 20:3; PE(20:3(5Z,8Z,11Z)/0:0) | [M-H]- | 3.73 | 502.2946 | 0.426↓ | 0.014 |
lysoPE 18:1; PE(18:1(17Z)/0:0) | [M-H]- | 4.02 | 478.2952 | 0.401↓ | 0.014 | |
lysoPE 18:2; PE(18:2(6Z,9Z)/0:0) | [M-H]- | 3.26 | 476.2791 | 0.346↓ | 0.007 | |
lysoPE 22:5; PE(22:5(4Z,7Z,10Z,13Z,16Z)/0:0) | [M-H]- | 3.27 | 526.2956 | 0.388↓ | 0.014 | |
26 | lysoPE 18:3; PE(18:3(6Z,9Z,12Z)/0:0) | [M-H]- | 2.89 | 474.2632 | 0.380↓ | 0.002 |
27 | lysoPE 22:6; PE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0) | [M-H]- | 3.12 | 524.2782 | 0.338↓ | 0.003 |
28 | lysoPE 20:4; PE(20:4(5Z,8Z,11Z,14Z)/0:0) | [M-H]- | 3.29 | 500.2796 | 0.332↓ | 0.003 |
29 | lysoPE 22:4; PE(22:4(7Z,10Z,13Z,16Z)/0:0) | [M-H]- | 3.9 | 528.311 | 0.309↓ | 0.014 |