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Table 3 Effect of Nicotinamide, Vitamin b2 and Vitamin C on hepatic MDA (nmol/mg), GSH (μmol/g tissue), catalase (U/g tissue), SOD (U/g tissue), NO (nmol/g,Hydroxyproline (Ug/g tissue) and plasma TNF-α (Pg/ml)

From: Potential effects of the combination of nicotinamide, vitamin B2 and vitamin C on oxidative-mediated hepatotoxicity induced by thioacetamide

 

Control

TAA

TAA + NA

TAA + VB2

TAA + VC

TAA + NA,VB2,VC

MDA

6.43 ± 0.23

11.78 ± 0.45a

8.59 ± 0.42a,b

9.04 ± 0.47a,b

8.16 ± 0.32a,b

7.35 ± 0.16a,b,c

GSH

32.78 ± 1.06

19.68 ± .0.30a

23.79 ± 0.51a,b

23.55 ± 1.02a,b

25.82 ± 0.54a,b

29.48 ± 0.49b,c

Catalase

503.17 ± 30.00

266.84 ± 22.57a

400.46 ± 20.33a,b

370.16 ± 12.93a,b

395.00 ± 18.71a,b

468.52 ± 8.75b,c

SOD

275.43 ± 8.41

131.73 ± 6.98a

200.17 ± 11.07a,b

180.00 ± 4.51a,b

188.72 ± 9.12a,b

249.84 ± 8.26b,c

NO

65.78 ± 3.18

127.34 ± 6.38a

80.67 ± 3.74a,b

93.08 ± 4.11a,b

88.71 ± 3.53a,b

74.96 ± 2.56b

H.Prol

112.47 ± 6.32

763.71 ± 21.49a

426.85 ± 10.65a,b

512.67 ± 17.53a,b

459.27 ± 13.89a,b

342.79 ± 8.29a,b,c

TNF-α

12.42 ± 0.25

76.28 ± 1.03a

44.90 ± 0.56a,b

60.85 ± 0.52a,b

53.67 ± 0.36a,b

36.42 ± 0.11a,b,c

  1. aSignificant difference from control
  2. bSignificant difference from TAA group
  3. cSignificant difference from TAA + NA, TAA + VB2, TAA + VC