DOCK7-ANGPTL3 SNPs and their haplotypes with serum lipid levels and the risk of coronary artery disease and ischemic stroke

Table 1 General characteristic of the participants

Characteristic	Control (n = 621)	CAD (n = 568)	IS (n = 539)	P _CAD	P _IS
Male/Female	449/172	418/150	389/150	0.617	0.960
Age, year	61.67 ± 11.99	62.26 ± 10.55	62.81 ± 12.37	0.739	0.868
BMI (kg/m²)	22.65 ± 3.20	23.91 ± 3.26	23.39 ± 3.54	0.006	0.009
Systolic blood pressure, mmHg	128.26 ± 19.00	133.16 ± 23.49	147.52 ± 22.00	0.000	0.004
Diastolic blood pressure, mmHg	80.56 ± 11.41	79.19 ± 14.27	83.71 ± 12.93	0.022	0.003
Pulse pressure, mmHg	47.70 ± 13.74	53.98 ± 17.68	63.81 ± 17.76	0.000	0.000
Cigarette smoking, n (%)	244 (39.2)	244 (43.0)	221 (41.6)	0.199	0.553
Alcohol consumption, n (%)	270 (43.4)	130 (22.9)	150 (28.2)	0.000	0.000
Total cholesterol, mmol/L	4.88 ± 1.06	4.54 ± 1.20	4.52 ± 1.15	0.007	0.031
Triglyceride, mmol/L	1.37 (1.78)	1.67 (1.12)	1.62 (1.38)	0.748	0.465
HDL-C (mmol/L)	1.90 ± 0.48	1.14 ± 0.34	1.23 ± 0.40	0.000	0.000
LDL-C (mmol/L)	2.73 ± 0.78	2.71 ± 1.00	2.68 ± 0.90	0.000	0.000
Apolipoprotein (Apo) A1, g/L	1.41 ± 0.27	1.02 ± 0.32	1.02 ± 0.23	0.895	0.051
ApoB, g/L	0.90 ± 0.21	0.91 ± 0.27	0.89 ± 0.24	0.000	0.080
ApoA1/ApoB	1.64 ± 0.51	1.30 ± 1.83	1.27 ± 0.60	0.210	0.745

CAD coronary artery disease, IS ischemic stroke, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, P_CAD, the P value between CAD patients and controls; P_IS, the P value between IS patients and controls. The value of triglyceride was median (interquartile range), the difference between CAD/IS patients and controls was determined by the Wilcoxon-Mann-Whitney test

ISSN: 1476-511X