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Table 4 Genotypes of the two DOCK7-ANGPTL3 SNPs and the risk of CAD and IS

From: DOCK7-ANGPTL3 SNPs and their haplotypes with serum lipid levels and the risk of coronary artery disease and ischemic stroke

SNP/Model

Ref. Genotype

Effect Genotype

(OR 95% CI)CAD

P CAD

IS (OR 95% CI)IS

P IS

rs1748195

 Codominant

CC

CG

1.16 (0.88-1.54)

0.058

0.93 (0.69–1.6)

0.221

  

GG

1.90 (1.10–3.29)

 

1.59 (0.89–2.84)

 

 Dominant

CC

CG/GG

1.25 (0.96–1.64)

0.098

1.01 (0.76–1.35)

0.933

 Recessive

CC/CG

GG

1.79 (1.04–3.06)

0.017

1.63 (0.92–2.88)

0.092

 Overdomiant

CC/GG

CG

1.09 (0.83–1.43)

0.552

0.89 (0.66–1.19)

0.439

 Log–additve

–

–

1.27 (1.02–1.57)

0.014

1.09 (0.87–1.37)

0.450

Rs12563308

 Codominant

TT

CT

0.67 (0.44–1.03)

0.192

0.75 (0.48–1.16)

0.408

  

CC

1.17 (0.17–7.99)

 

1.28 (0.15–11.62)

 

 Dominant

TT

CT/CC

0.69 (0.45–0.94)

0.011

0.76 (0.49–1.17)

0.206

 Recessive

TT/CT

CC

1.23 (0.18–8.44)

0.834

1.33 (0.15–11.62)

0.799

 Overdomiant

TT/CC

CT

0.67 (0.44–1.03)

0.068

0.75 (0.48–1.16)

0.187

 Log–additve

–

–

0.73 (0.49–0.89)

0.009

0.79 (0.53–1.19)

0.264

  1. SNP single nucleotide polymorphisms, CAD coronary artery disease, IS ischemic disease, OR (95%CI) Odds ratio (OR) and 95% confidence interval (CI) between patients and controls