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Table 6 The PI values for interactions of genotypes and drinking, smoking, and BMI on serum lipid levels and angiographic severity of coronary atherosclerosis in CAD

From: DOCK7-ANGPTL3 SNPs and their haplotypes with serum lipid levels and the risk of coronary artery disease and ischemic stroke

SNP/Factor

Lipid

P CAS

TC

TG

HDL-C

LDL-C

ApoA1

ApoB

ApoA1/B

Rs1748195

 Sex

0.987

0.417

0.561

0.942

0.403

0.632

0.948

0.18

 Age

0.591

0.790

0.435

0.145

0.842

0.621

0.957

0.40

 BMI

0.810

0.705

0.728

0.878

0.446

0.493

0.481

0.02

 Smoking

0.552

0.876

0.840

0.194

0.209

0.816

0.949

0.50

 Drinking

0.374

0.609

0.903

0.483

0.564

0.002

0.142

0.98

Rs12563308

 Sex

0.457

0.603

0.840

0.849

0.707

0.998

0.867

0.85

 Age

0.800

0.982

0.140

0.247

0.104

0.365

0.210

0.56

 BMI

0.380

0.517

0.209

0.236

0.307

0.082

0.001

0.17

 Smoking

0.596

0.941

0.497

0.384

0.473

0.618

0.527

0.45

 Drinking

0.002

0.562

0.180

0.267

0.099

0.228

0.208

0.31

  1. SNP single nucleotide polymorphism, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, CAD coronary artery disease, IS ischemic stroke, BMI body mass index. The PI values for interactions were detected by ANCOA, and a P ≤ 0.005 was considered statistically significant after Bonferroni correction; PCAS, the P interaction value of angiographic severity to coronary atherosclerosis in CAD patients, and the Polytomous Logistic Regression for Ordinal Response was employeed. A PCAS ≤ 0.025 was considered statistically significant after the rest four environmental factors was adjusted when one of the environmental factors interactions was detected
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Lipids in Health and Disease

ISSN: 1476-511X