Group | Haplotype | Control Fre. | Case Fre. | OR (95% CI) |
P
| LD |
---|
D’
|
r
2
|
---|
CAS | C–T | 0.7643 | 0.7064 | 1 |  |  |  |
G–T | 0.1815 | 0.2486 | 1.46 (1.05–2.03) | 0.023 | – | – |
G–C | 0.0541 | 0.0434 | 0.93 (0.51–1.69) | 0.820 |
Rare | * | * | Â | Â | Â | Â |
CAD | C–T | 0.7554 | 0.7224 | 1 |  |  |  |
G–T | 0.1722 | 0.2300 | 1.37 (1.08–1.74) | 0.009 | 0.8838 | 0.3833 |
G–C | 0.0638 | 0.0464 | 0.90 (0.59–1.37) | 0.630 |
Rare | * | * | Â | Â | Â | Â |
IS | C–T | 0.7554 | 0.7514 | 1 |  |  |  |
G–T | 0.1722 | 0.1902 | 1.12 (0.87–1.45) | 0.372 | 0.9060 | 0.4263 |
G–C | 0.0638 | 0.0584 | 0.95 (0.62–1.46) | 0.811 |
Rare | * | * | Â | Â | Â | Â |
- Control Fre. the frequency of haplotypes in controls, Case Fre. the frequency of haplotypes in CAD/IS patients, CAS coronary atherosclerosis. Group CAS, according to angiographic severity in CAD patients, only one–vessel and more than one–vessel in the three major in the three major coronary arteries were defined as control and case respectively; Group CAD/IS, all the patients in our research; the risk of severity to atherosclerosis and CAD/IS was obtained by unconditional logistic regression, and a P < 0.05 was considered statistically significant after sex, age, BMI, drinking, smoking, hypertension, hyperlipidemia were adjusted; *, the values of the rare haplotypes were not listed