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Table 8 Linkage disequilibrium analysis of the DOCK7–ANGPTL3 SNPs and the association of haplotypes and the risk of atherosclerosis, CAD and IS

From: DOCK7-ANGPTL3 SNPs and their haplotypes with serum lipid levels and the risk of coronary artery disease and ischemic stroke

Group

Haplotype

Control Fre.

Case Fre.

OR (95% CI)

P

LD

D’

r 2

CAS

C–T

0.7643

0.7064

1

   

G–T

0.1815

0.2486

1.46 (1.05–2.03)

0.023

–

–

G–C

0.0541

0.0434

0.93 (0.51–1.69)

0.820

Rare

*

*

    

CAD

C–T

0.7554

0.7224

1

   

G–T

0.1722

0.2300

1.37 (1.08–1.74)

0.009

0.8838

0.3833

G–C

0.0638

0.0464

0.90 (0.59–1.37)

0.630

Rare

*

*

    

IS

C–T

0.7554

0.7514

1

   

G–T

0.1722

0.1902

1.12 (0.87–1.45)

0.372

0.9060

0.4263

G–C

0.0638

0.0584

0.95 (0.62–1.46)

0.811

Rare

*

*

    
  1. Control Fre. the frequency of haplotypes in controls, Case Fre. the frequency of haplotypes in CAD/IS patients, CAS coronary atherosclerosis. Group CAS, according to angiographic severity in CAD patients, only one–vessel and more than one–vessel in the three major in the three major coronary arteries were defined as control and case respectively; Group CAD/IS, all the patients in our research; the risk of severity to atherosclerosis and CAD/IS was obtained by unconditional logistic regression, and a P < 0.05 was considered statistically significant after sex, age, BMI, drinking, smoking, hypertension, hyperlipidemia were adjusted; *, the values of the rare haplotypes were not listed