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Table 4 Effect of theaflavin and thearubigins and their combination based intervention on body weight serum triglycerides (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), total cholesterol (TC), glucose and insulin in normal, hypercholestrolemic and hyperglycemic rats at the termination of the study

From: Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders

Parameters Baseline values Treatments Normal rats
(Study I)
Hypocholestrolemic rats
(Study II)
Hyperglycemic rats
(Study III)
Trial 1 Trial 2 Trial 1 Trial 2 Trial 1 Trial 2
Body weight (at termination of study) 128 ± 10.25 T0 (Control) 225 ± 4.21a 228 ± 5.01a 255 ± 7.51a 253 ± 6.25a 243 ± 6.21a 240 ± 7.25a
T1 215.30 ± 4.14c 216.13 ± 5.21c 231.74 ± 7.12d 227.17 ± 6.12d 224.78 ± 7.23c 223.24 ± 9.21c
T2 220.48 ± 5.52ab 220.21 ± 4.13ab 242.28 ± 6.12b 240.20 ± 5.43b 232.94 ± 5.34ab 228.74 ± 6.21ab
T3 218.22 ± 7.25b 217.30 ± 8.42b 237.12 ± 6.91c 235.57 ± 5.62c 230.34 ± 7.21b 228.02 ± 5.21b
TC (mg/dL) 77.80 ± 3.56 T0 (Control) 80.25 ± 4.21 83.27 ± 5.01 148 ± 7.51a 145 ± 6.25a 97 ± 3.21a 95 ± 4.25a
T1 77.24 ± 4.14 80.81 ± 5.21 131.67 ± 7.02d 129.58 ± 6.14d 89.60 ± 5.21c 87.35 ± 3.21c
T2 78.68 ± 5.52 82.08 ± 4.13 141.50 ± 6.12b 136.53 ± 5.43b 92.96 ± 5.34b 90.65 ± 6.21b
T3 77.87 ± 2.25 81.23 ± 3.41 137.65 ± 6.91c 134.60 ± 5.62c 91.05 ± 7.21b 90.00 ± 5.21b
LDL-C (mg/dL) 26.56 ± 3.56 T0 (Control) 30.08 ± 1.26 28.09 ± 2.31 61.74 ± 2.31a 59.45 ± 3.13a 48.36 ± 3.51a 46.86 ± 4.13a
T1 28.91 ± 1.83 26.95 ± 1.98 52.94 ± 3.92d 50.47 ± 2.13d 43.31 ± 2.91c 41.19 ± 2.33c
T2 29.69 ± 1.32 27.54 ± 1.96 57.02 ± 4.14b 54.61 ± 3.90b 45.93 ± 2.92b 44.00 ± 2.57b
T3 29.11 ± 1.64 26.97 ± 1.43 55.42 ± 2.51c 52.21 ± 3.12c 44.50 ± 3.63b 43.05 ± 3.54b
HDL-C (mg/dL) 32.56 ± 3.56 T0 (Control) 35.76 ± 2.35 37.47 ± 3.35 57.67 ± 4.11b 59.22 ± 3.62b 40.55 ± 1.09b 41.56 ± 2.03b
T1 36.83 ± 2.61 38.47 ± 1.09 60.70 ± 5.32a 62.45 ± 5.62a 42.31 ± 3.22a 43.33 ± 4.54a
T2 36.22 ± 2.51 38.04 ± 2.11 58.96 ± 5.12b 60.58 ± 3.63b 41.28 ± 3.12ab 42.35 ± 2.90ab
T3 36.76 ± 2.11 38.31 ± 1.61 60.06 ± 3.92a 61.80 ± 4.11a 42.17 ± 3.91a 43.12 ± 2.80a
TG (mg/dL) 58.26 ± 3.56 T0 (Control) 65.73 ± 5.21 67.47 ± 4.23 98.88 ± 7.02a 95.01 ± 6.52a 78.99 ± 5.13a 76.14 ± 6.31a
T1 63.76 ± 2.03 65.44 ± 4.12 90.43 ± 7.05d 87.45 ± 6.35d 73.82 ± 5.10c 70.79 ± 3.19c
T2 64.68 ± 3.20 66.11 ± 4.01 95.13 ± 5.81b 91.19 ± 6.02b 76.01 ± 6.21b 73.09 ± 5.69b
T3 64.01 ± 3.08 65.88 ± 4.02 92.26 ± 7.01c 88.35 ± 5.03c 74.94 ± 4.15b 71.56 ± 5.21b
Glucose (mg/dL) 79.63 ± 3.72 T0 (Control) 85.13 ± 6.23 87.60 ± 5.03 100.34 ± 8.52a 98.02 ± 7.13a 135.19 ± 9.99a 140.91 ± 8.54a
T1 82.57 ± 4.52 85.10 ± 6.12 93.95 ± 8.25b 90.76 ± 8.56b 122.85 ± 9.63c 128.49 ± 9.25c
T2 82.61 ± 6.02 85.84 ± 5.86 92.13 ± 6.98b 94.41 ± 7.45b 126.04 ± 9.45b 132.18 ± 7.46b
T3 81.74 ± 3.25 84.22 ± 4.86 91.49 ± 7.84c 88.44 ± 6.98c 120.28 ± 8.51d 123.67 ± 6.35d
Insulin μU/Ml 6.23 ± 0.56 T0 (Control) 7.59 ± 0.65 8.74 ± 0.70 9.56 ± 0.36b 10.89 ± 0.35b 12.02 ± 1.01bc 13.37 ± 1.12bc
T1 7.81 ± 0.15 9.01 ± 0.32 10.03 ± 0.92a 11.33 ± 0.45a 12.97 ± 1.22a 14.39 ± 1.32a
T2 7.75 ± 0.61 8.94 ± 0.81 9.83 ± 0.94a 11.19 ± 0.84a 12.47 ± 1.21b 13.85 ± 1.23b
T3 7.84 ± 0.45 9.10 ± 0.41 10.09 ± 0.15a 11.59 ± 0.86a 13.02 ± 1.02a 14.55 ± 1.13a
Glutathione mg/L 49.01 ± 2.01 T0 (Control) 48.49 ± 3.12c 49.51 ± 2.98c 38.27 ± 3.12c 39.45 ± 3.15d 41.23 ± 2.09c 40.28 ± 3.06c
T1 50.43 ± 2.92ab 51.97 ± 3.15ab 41.72 ± 2.35b 43.40 ± 3.55b 44.22 ± 3.47b 43.59 ± 3.12b
T2 49.49 ± 2.10b 51.41 ± 2.12b 40.23 ± 2.98bc 41.81 ± 2.12c 43.30 ± 3.71bc 42.36 ± 3.51bc
T3 51.47 ± 1.21a 52.46 ± 3.91a 45.73 ± 2.98a 46.93 ± 4.12a 48.24 ± 4.01a 46.99 ± 4.11a
TBARS μmol/L   T0 (Control) 6.97 ± 0.02a 7.51 ± 0.05a 10.15 ± 0.07a 9.30 ± 0.09a 8.08 ± 0.10a 8.63 ± 0.14a
T1 6.57 ± 0.01b 7.09 ± 0.51b 8.31 ± 0.42c 7.71 ± 0.01c 6.93 ± 0.42c 7.44 ± 0.53c
T2 6.76 ± 0.04a 7.28 ± 0.01a 9.64 ± 0.02b 8.88 ± 0.01b 7.75 ± 0.03b 8.21 ± 0.02b
T3 6.63 ± 0.01b 7.14 ± 0.03b 9.26 ± 0.01bc 8.54 ± 0.05bc 7.51 ± 0.04b 7.85 ± 0.03c
  1. Values are mean ± SEM (n = 05). Descriptive Statistics were applied to check the overall behavior of the study parameter to elaborate the effect of treatments on selected parameter of rats. Values in same column within each parameter with different letters were significantly different from each other
  2. NS Non Significant
  3. Study I: Normal rats
  4. Study II: Hypercholestrolemic rats
  5. Study III: Hyperglycemic rats
  6. T0: Control drink (without active ingredients)
  7. T1: Drink containing Theaflavin
  8. T2: Drink containing Thearubigins
  9. T3: Drink containing Theaflavin + Thearubigins
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