From: Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders
Parameters | Baseline values | Treatments | Normal rats (Study I) | Hypocholestrolemic rats (Study II) | Hyperglycemic rats (Study III) | |||
---|---|---|---|---|---|---|---|---|
Trial 1 | Trial 2 | Trial 1 | Trial 2 | Trial 1 | Trial 2 | |||
Body weight (at termination of study) | 128 ± 10.25 | T0 (Control) | 225 ± 4.21a | 228 ± 5.01a | 255 ± 7.51a | 253 ± 6.25a | 243 ± 6.21a | 240 ± 7.25a |
T1 | 215.30 ± 4.14c | 216.13 ± 5.21c | 231.74 ± 7.12d | 227.17 ± 6.12d | 224.78 ± 7.23c | 223.24 ± 9.21c | ||
T2 | 220.48 ± 5.52ab | 220.21 ± 4.13ab | 242.28 ± 6.12b | 240.20 ± 5.43b | 232.94 ± 5.34ab | 228.74 ± 6.21ab | ||
T3 | 218.22 ± 7.25b | 217.30 ± 8.42b | 237.12 ± 6.91c | 235.57 ± 5.62c | 230.34 ± 7.21b | 228.02 ± 5.21b | ||
TC (mg/dL) | 77.80 ± 3.56 | T0 (Control) | 80.25 ± 4.21 | 83.27 ± 5.01 | 148 ± 7.51a | 145 ± 6.25a | 97 ± 3.21a | 95 ± 4.25a |
T1 | 77.24 ± 4.14 | 80.81 ± 5.21 | 131.67 ± 7.02d | 129.58 ± 6.14d | 89.60 ± 5.21c | 87.35 ± 3.21c | ||
T2 | 78.68 ± 5.52 | 82.08 ± 4.13 | 141.50 ± 6.12b | 136.53 ± 5.43b | 92.96 ± 5.34b | 90.65 ± 6.21b | ||
T3 | 77.87 ± 2.25 | 81.23 ± 3.41 | 137.65 ± 6.91c | 134.60 ± 5.62c | 91.05 ± 7.21b | 90.00 ± 5.21b | ||
LDL-C (mg/dL) | 26.56 ± 3.56 | T0 (Control) | 30.08 ± 1.26 | 28.09 ± 2.31 | 61.74 ± 2.31a | 59.45 ± 3.13a | 48.36 ± 3.51a | 46.86 ± 4.13a |
T1 | 28.91 ± 1.83 | 26.95 ± 1.98 | 52.94 ± 3.92d | 50.47 ± 2.13d | 43.31 ± 2.91c | 41.19 ± 2.33c | ||
T2 | 29.69 ± 1.32 | 27.54 ± 1.96 | 57.02 ± 4.14b | 54.61 ± 3.90b | 45.93 ± 2.92b | 44.00 ± 2.57b | ||
T3 | 29.11 ± 1.64 | 26.97 ± 1.43 | 55.42 ± 2.51c | 52.21 ± 3.12c | 44.50 ± 3.63b | 43.05 ± 3.54b | ||
HDL-C (mg/dL) | 32.56 ± 3.56 | T0 (Control) | 35.76 ± 2.35 | 37.47 ± 3.35 | 57.67 ± 4.11b | 59.22 ± 3.62b | 40.55 ± 1.09b | 41.56 ± 2.03b |
T1 | 36.83 ± 2.61 | 38.47 ± 1.09 | 60.70 ± 5.32a | 62.45 ± 5.62a | 42.31 ± 3.22a | 43.33 ± 4.54a | ||
T2 | 36.22 ± 2.51 | 38.04 ± 2.11 | 58.96 ± 5.12b | 60.58 ± 3.63b | 41.28 ± 3.12ab | 42.35 ± 2.90ab | ||
T3 | 36.76 ± 2.11 | 38.31 ± 1.61 | 60.06 ± 3.92a | 61.80 ± 4.11a | 42.17 ± 3.91a | 43.12 ± 2.80a | ||
TG (mg/dL) | 58.26 ± 3.56 | T0 (Control) | 65.73 ± 5.21 | 67.47 ± 4.23 | 98.88 ± 7.02a | 95.01 ± 6.52a | 78.99 ± 5.13a | 76.14 ± 6.31a |
T1 | 63.76 ± 2.03 | 65.44 ± 4.12 | 90.43 ± 7.05d | 87.45 ± 6.35d | 73.82 ± 5.10c | 70.79 ± 3.19c | ||
T2 | 64.68 ± 3.20 | 66.11 ± 4.01 | 95.13 ± 5.81b | 91.19 ± 6.02b | 76.01 ± 6.21b | 73.09 ± 5.69b | ||
T3 | 64.01 ± 3.08 | 65.88 ± 4.02 | 92.26 ± 7.01c | 88.35 ± 5.03c | 74.94 ± 4.15b | 71.56 ± 5.21b | ||
Glucose (mg/dL) | 79.63 ± 3.72 | T0 (Control) | 85.13 ± 6.23 | 87.60 ± 5.03 | 100.34 ± 8.52a | 98.02 ± 7.13a | 135.19 ± 9.99a | 140.91 ± 8.54a |
T1 | 82.57 ± 4.52 | 85.10 ± 6.12 | 93.95 ± 8.25b | 90.76 ± 8.56b | 122.85 ± 9.63c | 128.49 ± 9.25c | ||
T2 | 82.61 ± 6.02 | 85.84 ± 5.86 | 92.13 ± 6.98b | 94.41 ± 7.45b | 126.04 ± 9.45b | 132.18 ± 7.46b | ||
T3 | 81.74 ± 3.25 | 84.22 ± 4.86 | 91.49 ± 7.84c | 88.44 ± 6.98c | 120.28 ± 8.51d | 123.67 ± 6.35d | ||
Insulin μU/Ml | 6.23 ± 0.56 | T0 (Control) | 7.59 ± 0.65 | 8.74 ± 0.70 | 9.56 ± 0.36b | 10.89 ± 0.35b | 12.02 ± 1.01bc | 13.37 ± 1.12bc |
T1 | 7.81 ± 0.15 | 9.01 ± 0.32 | 10.03 ± 0.92a | 11.33 ± 0.45a | 12.97 ± 1.22a | 14.39 ± 1.32a | ||
T2 | 7.75 ± 0.61 | 8.94 ± 0.81 | 9.83 ± 0.94a | 11.19 ± 0.84a | 12.47 ± 1.21b | 13.85 ± 1.23b | ||
T3 | 7.84 ± 0.45 | 9.10 ± 0.41 | 10.09 ± 0.15a | 11.59 ± 0.86a | 13.02 ± 1.02a | 14.55 ± 1.13a | ||
Glutathione mg/L | 49.01 ± 2.01 | T0 (Control) | 48.49 ± 3.12c | 49.51 ± 2.98c | 38.27 ± 3.12c | 39.45 ± 3.15d | 41.23 ± 2.09c | 40.28 ± 3.06c |
T1 | 50.43 ± 2.92ab | 51.97 ± 3.15ab | 41.72 ± 2.35b | 43.40 ± 3.55b | 44.22 ± 3.47b | 43.59 ± 3.12b | ||
T2 | 49.49 ± 2.10b | 51.41 ± 2.12b | 40.23 ± 2.98bc | 41.81 ± 2.12c | 43.30 ± 3.71bc | 42.36 ± 3.51bc | ||
T3 | 51.47 ± 1.21a | 52.46 ± 3.91a | 45.73 ± 2.98a | 46.93 ± 4.12a | 48.24 ± 4.01a | 46.99 ± 4.11a | ||
TBARS μmol/L |  | T0 (Control) | 6.97 ± 0.02a | 7.51 ± 0.05a | 10.15 ± 0.07a | 9.30 ± 0.09a | 8.08 ± 0.10a | 8.63 ± 0.14a |
T1 | 6.57 ± 0.01b | 7.09 ± 0.51b | 8.31 ± 0.42c | 7.71 ± 0.01c | 6.93 ± 0.42c | 7.44 ± 0.53c | ||
T2 | 6.76 ± 0.04a | 7.28 ± 0.01a | 9.64 ± 0.02b | 8.88 ± 0.01b | 7.75 ± 0.03b | 8.21 ± 0.02b | ||
T3 | 6.63 ± 0.01b | 7.14 ± 0.03b | 9.26 ± 0.01bc | 8.54 ± 0.05bc | 7.51 ± 0.04b | 7.85 ± 0.03c |