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Table 10 Impact of effective dose of various compounds in different cancer cell lines

From: Proteasome inhibitors modulate anticancer and anti-proliferative properties via NF-kB signaling, and ubiquitin-proteasome pathways in cancer cell lines of different organs

#

 

Hela cells

Liver cancer cells

Pancreas cancer cells

Prostate cancer cells

Breast cancer cells

Lung cancer cells

Melanoma cells

B-Lymphocyte cells

T-cells (Jurkat)

  

1

2

3

4

5

6

7

8

9

 

Compounds

μM; value (%)a

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

1

Thiostrepton

40; 8.7 ± 1.5 (16)a

10; 6.7 ± 2.2 (8)

10; 7.7 ± 0.6 (16)

5; 7.0 ± 1.7 (19)

10; 6.7 ± 0.6 (29)

5; 7.0 ± 2.0 (28)

5; 2.3 ± 1.5 (13)

2.5; 15.7 ± 4.0 (23)

2.5; 21.3 ± 2.1 (5)

2

Ampicillin

80; 47.7 ± 5.5 (88)

40; 70.3 ± 4.2 (88)

80; 35.3 ± 5.0 (74)

20; 15.0 ± 1.0 (41)

40; 16.7 ± 6.1 (74)

80; 21.3 ± 1.5 (85)

20; 12.3 ± 1.2 (70)

10; 44.7 ± 5.1 (66)

20; 450.3 ± 15.6 (94)

3

Dexamethasone

80; 18.0 ± 4.0 (53)

80; 67.3 ± 4.0 (93)

20; 34.7 ± 4.0 (73)

20; 16.7 ± 1.5 (32)

80; 15.7 ± 3.1 (85)

20; 16.7 ± 2.1 (76)

40; 13.0 ± 2.7 (74)

10; 61.0 ± 3.6 (41)

40; 282.0 ± 21.7 (71)

4

2-Methoxyestradiol

20; 4.3 ± 1.5 (13)

10; 19.7 ± 2.1 (27)

40; 20.0 ± 2.0 (42)

10; 1.7 ± 1.5 (30)

20; 8.0 ± 2.0 (44)

10; 2.3 ± 1.5 (11)

10; 2.0 ± 1.7 (11)

5; 4.0 ± 2.0 (33)

5; 31.3 ± 5.7 (8)

5

δ-Tocotrienol

20; 8.3 ± 2.1 (18)

20; 17.7 ± 2.1 (24)

20; 5.7 ± 1.5 (5)

20; 12.3 ± 1.5 (35)

20; 10.7 ± 0.6 (56)

20; 8.3 ± 2.1 (11)

20; 7.0 ± 3.6 (37)

20; 2.7 ± 1.5 (21)

5; 31.3 ± 5.7 (8)

6

(−) Riboflavin

40; 21.0 ± 1.0 (64)

80; 74.0 ± 2.0 (91)

40; 40.0 ± 2.0 (67)

40; 20.0 ± 2.0 (61)

80; 12.7 ± 1.5 (61)

10; 7.7 ± 2.1 (23)

40; 26.3 ± 3.1 (91)

20; 19.3 ± 3.1 (69)

20; 142.0 ± 4.4 (32)

7

Ascorbic Acid

80; 21.0 ± 0.1 (64)

80; 74.3 ± 2.5 (90)

80; 42.3 ± 2.5 (71)

80; 29.3 ± 2.1 (81)

40; 15.0 ± 1.7 (73)

20; 15.0 ± 4.4 (46)

80; 23.7 ± 4.7 (81)

20; 17.3 ± 2.5 (62)

40; 451.3 ± 32.4 (89)

8

Quercetin

40; 21.3 ± 1.5 (38)

40; 24.0 ± 2.0 (29)

40; 11.7 ± 0.6 (26)

20; 7.3 ± 1.2 (17)

20; 5.7 ± 0.6 (27)

20; 11.7 ± 1.5 (36)

40; 8.3 ± 0.6 (21)

10; 8.0 ± 3.0 (29)

40; 409.3 ± 6.4 (81)

9

Amiloride-HCL

80; 19.7 ± 1.5 (36)

40; 36.7 ± 2.5 (65)

80; 30.7 ± 1.2 (69)

80; 27.0 ± 4.6 (70)

20; 14.0 ± 5.3 (61)

40; 23.3 ± 2.5 (86)

40; 33.0 ± 5.6 (90)

20; 5.0 ± 1.0 (56)

20; 132.7 ± 2.1 (38)

10

(−) Corey Lactone

80; 36.0 ± 5.6 (66)

80; 31.7 ± 2.1 (56)

40; 30.7 ± 1.2 (58)

40; 23.3 ± 2.1 (60)

40; 17.7 ± 3.2 (77)

40; 17.3 ± 3.8 (64)

40; 18.3 ± 3.5 (62)

20; 5.3 ± 1.5 (59)

40; 280.3 ± 10.2 (64)

11

Quinine Sulphate

20; 10.7 ± 1.5 (19)

80; 47.7 ± 2.1 (58)

40; 35.0 ± 3.0 (78)

20; 15.7 ± 2.1 (36)

80; 12.3 ± 2.3 (60)

40; 21.3 ± 1.5 (66)

20; 22.7 ± 2.9 (56)

80; 20.3 ± 3.1 (19)

40; 267.7 ± 29.7 (77)

  1. aPercentage of control values are in parentheses
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Lipids in Health and Disease

ISSN: 1476-511X