Skip to main content

Table 11 The IC50 values of various compounds in different cancer cell lines

From: Proteasome inhibitors modulate anticancer and anti-proliferative properties via NF-kB signaling, and ubiquitin-proteasome pathways in cancer cell lines of different organs

#

 

Hela cells

Liver cancer cells

Pancreas cancer cells

Prostate cancer cells

Breast cancer cells

Lung cancer cells

Melanoma cells

B-Lymphocyte cells

T-cells (Jurkat)

  

1

2

3

4

5

6

7

8

9

 

Compounds

μM; value (%)a

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

μM; value (%)

1

Thiostrepton

10; 13.3 ± 0.6 (24)a

2.5; 42.3 ± 3.5 (53)

5; 14.0 ± 1.0 (29)

2.5; 19.7 ± 0.6 (53)

20; 3.7 ± 1.5 (16)

5; 7.0 ± 2.0 (48)

2.5; 6.0 ± 2.0 (34)

2.5; 15.7 ± 4.0 (23)

2.5; 21.3 ± 2.1 (5)

2

Ampicillin

   

5; 18.3 ± 1.5 (50)

     

3

Dexamethasone

20; 18.3 ± 4.2 (54)

  

2.5; 23.3 ± 2.0 (45)

 

2.5; 10.3 ± 2.1 (47)

 

5; 66.0 ± 5.3 (45)

 

4

2-Methoxyestradiol

2.5; 16.3 ± 1.5 (48)

5; 32.7 ± 2.5 (45)

40; 20.0 ± 2.0 (42)

2.5; 20.0 ± 2.0 (39)

10; 8.3 ± 2.9 (45)

2.5; 3.7 ± 1.2 (17)

2.5; 4.3 ± 0.6 (25)

2.5; 8.0 ± 2.0 (5)

2.5; 32.7 ± 5.0 (8)

5

δ-Tocotrienol

5; 20.7 ± 1.2 (45)

20; 38.3 ± 5.9 (53)

10; 18.0 ± 2.0 (36)

10; 14.0 ± 2.0 (39)

10; 9.3 ± 2.1 (49)

20; 2.3 ± 2.1 (11)

10; 9.3 ± 3.1 (50)

10; 7.0 ± 2.1 (55)

20; 142.0 ± 4.4 (32)

6

(−) Riboflavin

   

80; 18.0 ± 2.0 (55)

 

2.5; 9.3 ± 2.5 (28)

 

80; 15.3 ± 3.5 (55)

 

7

Ascorbic Acid

     

10; 16.0 ± 4.6 (49)

   

8

Quercetin

10; 28.3 ± 8.1 (51)

20; 26.3 ± 3.5 (32)

40; 20.3 ± 2.1 (45)

10; 21.0 ± 3.6 (48)

10; 8.0 ± 1.7 (39)

10; 14.7 ± 2.5 (45)

10; 21.7 ± 7.1 (54)

10; 8.0 ± 3.0 (29)

10; 157.7 ± 20.5 (45)

9

Amiloride-HCL

10; 27.7 ± 2.1 (51)

80; 31.7 ± 2.1 (56)

  

40; 12.0 ± 2.0 (52)

  

40; 4.3 ± 1.5 (48)

 

10

(−) Corey Lactone

 

80; 31.7 ± 2.1 (56)

80; 28.7 ± 3.1 (54)

80; 19.7 ± 1.5 (51)

80; 12.7 ± 1.5 (55)

80; 12.0 ± 2.7 (44)

80; 13.7 ± 2.3 (46)

40; 3.3 ± 1.5 (37)

80; 124.3 ± 17.4 (29)

11

Quinine Sulphate

10; 15.3 ± 2.5 (24)

80; 47.7 ± 2.1 (58)

 

20; 15.7 ± 2.1 (36)

  

80; 20.3 ± 5.0 (50)

 

80; 174.7 ± 8.1 (50)

  1. aPercentage of control values are in parentheses