Plasma angiopoietin-like 4 is related to phospholipid transfer protein activity in diabetic and non-diabetic subjects: role of enhanced low grade inflammation

Table 2 Univariate relationships of angiopoietin-like 4 (ANGPLT4) levels and phospholipid transfer protein (PLTP) activity with clinical and laboratory variables in 77 subjects (41 subjects with and 36 subjects without Type 2 diabetes mellitus)

	ANGPTL4 (μg/l)	PLTP (AU)
ANGPTL4		0.309**
Age (years)	0.261*	0.159
Systolic blood pressure (mm Hg)	0.211*	0.286**
Diastolic blood pressure (mm Hg)	0.137	0.268*
BMI (kg/m²)	0.368***	0.420***
Glucose (mmol/l)	0.341**	0.433***
HbA1c (mmol/mol)	0.447***	0.390***
hsCRP (mg/l)	0.377***	0.373***
NEFA (mmol/l)	0.411***	0.304**
Total cholesterol (mmol/l)	−0.230*	0.209
Non-HDL cholesterol (mmol/l)	−0.209	0.214
LDL cholesterol (mmol/l)	−0.255*	0.178
HDL cholesterol (mmol/l)	−0.106	−0.256*
Triglycerides (mmol/l)	0.127	0.431***
ApoB (g/l)	−0.032	0.319**
ApoA-I (g/l)	−0.054	−0.119

Spearman correlation coefficients. Apo apolipoprotein, ANGPTL4 angiopoietin-like 4, BMI body mass index, HbA1c glycated hemoglobin, HDL high density lipoproteins, hsCRP high sensitivity C-reactive protein, LDL low density lipoproteins, NEFA non-esterfied fatty acids, PLTP phospholipid transfer protein. LDL cholesterol was calculated in 39 T2DM subjects and in 35 non-diabetic subjects. *p < 0.05; **p < 0.01: ***p < 0.001

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