Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population

Table 2 The association between tagger SNPs of SLC12A3 and LDL-C level by FBAT method

Marker^a	Allele and frequency^b		FBAT test statistics		P	P _-e ^d
Marker^a	Allele	Freq.	Var (S)	z ^c	P	P _-e ^d
Additive model
rs2304478	G:A	0.14	134.08	−2.47	0.014	–
rs5803	T:C	0.26	143.90	−2.06	0.039	0.022
rs7204044	G:A	0.11	102.28	−1.99	0.047	–
rs711746	G:A	0.45	197.57	2.22	0.027	0.039
Dominant model
rs2304478	G:A	0.14	93.68	−2.07	0.038	–
rs5803	T:C	0.26	84.56	−2.08	0.037	0.038
rs711746	G:A	0.45	103.24	2.09	0.036	0.023

Abbreviations: FBAT Family Based Association Test with the additive model, Freq. frequency of allele, Var (S) is a matrix, calculated under the null and used to standardize S
^aMarkers, which show significant association were demonstrated in this table; ^balleles detected in more than 10 informative families; and the lower frequency allele was used in following statistics calculation. ^cz-score calculated based on a biallelic marker model, positive z values and p < 0.05 indicated a high-risk haplotype; ^dp_e, significance test by FBAT with empirical variance estimator option [−e], non-significant markers displayed with hyphen (−)

ISSN: 1476-511X