Skip to main content

Table 3 Haplotype-base association test between SNPs of SLC12A3 and LDL-C level

From: Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population

Haplotypesa

Freq.

HBAT teststatistics

P

P -permutation b

Global P

Var(S)

z

   

rs5803(T/C)-rs711746(G/A)

   

 H1

C-A

0.40

133.45

0.70

0.482

0.486

0.028 c

 H2

C-G

0.38

134.59

1.81

0.071

0.069

 

 H3

T-A

0.18

93.02

−2.94

0.003 c

0.003 c

 
  1. Abbreviations: Freq. frequency of haplotypes, Var (S) is a matrix, calculated under the null hypothesis (g.e. no linkage and no association) and used to standardize S
  2. aHaplotypes, whose frequencies < 0.05 or number of informative families > 10, were excluded in table and in global p-value calculation; bp-permutation, whole haplotype permutation test (the default time is 10,000); cBold type denotes p < 0.05