Fig. 1

Association of APOE haplotypes (E2, E3, and E4) with total cholesterol concentrations in the Prevention of Cancer by Intervention with Selenium (PRECISE) study and Caerphilly Prospective study (CaPS). E2 allele carriers have significantly lower levels of total cholesterol than E3 (P = 0.001 and P = 4 × 10− 4 in the PRECISE and CaPS, respectively) and E4 (P = 2 × 10− 4 and P = 3 × 10− 6 in the PRECISE and CaPS, respectively) allele carriers