SNP
|
MAF
|
HDL-C (mmol/L)
|
Total Cholesterol (mmol/L)
|
LDL-C a (mmol/L)
|
---|
PRECISE
|
LPL
|
rs320
|
0.26
| | | |
TT
| |
1.6 ± 0.3
|
5.9 ± 1.1
| |
T/G
| |
1.7 ± 0.4
|
5.8 ± 1.0
| |
P value
| |
0.02
|
0.19
| |
rs328
|
0.10
| | | |
CC
| |
1.6 ± 0.3
|
5.9 ± 1.1
| |
C/G
| |
1.7 ± 0.4
|
5.7 ± 0.9
| |
P value
| |
0.04
|
0.06
| |
APOE
|
rs405509
|
0.47
| | | |
GG
| |
1.7 ± 0.4
|
5.8 ± 1.1
| |
GT
| |
1.5 ± 0.3
|
5.8 ± 1.1
| |
TT
| |
1.6 ± 0.3
|
6.1 ± 1.0
| |
P value
| |
0.07
|
0.23
| |
rs769450
|
0.39
| | | |
GG
| |
1.6 ± 0.3
|
5.9 ± 1.1
| |
A allele
| |
1.6 ± 0.4
|
5.9 ± 1.1
| |
P value
| |
0.72
|
0.97
| |
rs439401
|
0.33
| | | |
CC
| |
1.6 ± 0.4
|
5.9 ± 1.1
| |
T allele
| |
1.6 ± 0.3
|
5.9 ± 1.1
| |
P value
| |
0.43
|
0.51
| |
rs445925
|
0.11
| | | |
GG
| |
1.6 ± 0.3
|
5.9 ± 1.1
| |
A allele
| |
1.7 ± 0.4
|
5.6 ± 0.9
| |
P value
| |
0.25
|
0.003
| |
rs405697
|
0.25
| | | |
GG
| |
1.6 ± 0.4
|
5.9 ± 1.1
| |
A allele
| |
1.6 ± 0.3
|
5.9 ± 1.0
| |
P value
| |
0.71
|
0.96
| |
rs1160985
|
0.43
| | | |
CC
| |
1.6 ± 0.3
|
5.9 ± 1.1
| |
CT
| |
1.6 ± 0.4
|
5.8 ± 1.0
| |
TT
| |
1.7 ± 0.4
|
5.9 ± 1.1
| |
P value
| |
0.12
|
0.44
| |
rs1064725
|
0.04
| | | |
TT
| |
1.6 ± 0.4
|
5.9 ± 1.0
| |
G allele
| |
1.7 ± 0.3
|
6.1 ± 1.2
| |
P value
| |
0.17
|
0.38
| |
(rs7412- rs429358) E2, E3, and E4
|
E3
| |
1.6 ± 0.3
|
5.9 ± 1.1
| |
E4
| |
1.5 ± 0.3
|
6.1 ± 1.1
| |
E2
| |
1.7 ± 0.4
|
5.5 ± 0.9
| |
P value
| |
0.09
|
4X10−4
| |
Caerphilly
|
LPL
|
rs320
|
0.26
| | | |
TT
| |
1.3 ± 0.3
|
6.1 ± 1.1
|
2.7 ± 0.8
|
T/G
| |
1.4 ± 0.3
|
6.2 ± 1.2
|
2.8 ± 0.8
|
P value
| |
0.05
|
0.55
|
0.05
|
rs328
|
0.10
| | | |
CC
| |
1.3 ± 0.3
|
6.1 ± 1.1
|
2.7 ± 0.8
|
C/G
| |
1.3 ± 0.3
|
6.1 ± 1.1
|
2.9 ± 0.9
|
P value
| |
0.63
|
0.71
|
0.05
|
APOE
|
rs405509
|
0.46
| | | |
GG
| |
1.4 ± 0.3
|
6.0 ± 1.1
|
2.7 ± 0.9
|
GT
| |
1.3 ± 0.3
|
6.2 ± 1.1
|
2.8 ± 0.8
|
TT
| |
1.3 ± 0.3
|
6.3 ± 1.1
|
2.9 ± 0.9
|
P value
| |
0.16
|
0.02
|
0.29
|
rs769450
|
0.41
| | | |
GG
| |
1.3 ± 0.2
|
6.1 ± 1.2
|
2.8 ± 0.9
|
A allele
| |
1.4 ± 0.3
|
6.2 ± 1.1
|
2.8 ± 0.8
|
P value
| |
0.10
|
0.41
|
0.82
|
rs439401
|
0.35
| | | |
CC
| |
1.4 ± 0.3
|
6.2 ± 1.1
|
2.8 ± 0.9
|
T allele
| |
1.3 ± 0.3
|
6.1 ± 1.1
|
2.7 ± 0.8
|
P value
| |
0.72
|
0.42
|
0.32
|
rs445925
|
0.11
| | | |
GG
| |
1.3 ± 0.3
|
6.2 ± 1.1
|
2.8 ± 0.8
|
A allele
| |
1.3 ± 0.3
|
5.9 ± 1.2
|
2.5 ± 0.9
|
P value
| |
0.99
|
3X10−4
|
0.001
|
rs405697
|
0.26
| | | |
GG
| |
1.4 ± 0.4
|
6.1 ± 1.1
|
2.8 ± 0.9
|
A allele
| |
1.3 ± 0.3
|
6.1 ± 1.1
|
2.8 ± 0.8
|
P value
| |
0.30
|
0.88
|
0.9
|
rs1160985
|
0.45
| | | |
CC
| |
1.34 ± 0.29
|
6.2 ± 1.1
|
2.8 ± 0.9
|
CT
| |
1.35 ± 0.35
|
6.2 ± 1.2
|
2.7 ± 0.8
|
TT
| |
1.37 ± 0.40
|
6.1 ± 1.0
|
2.8 ± 0.8
|
P value
| |
0.61
|
0.30
|
0.73
|
rs1064725
|
0.01
| | | |
TT
| |
1.3 ± 0.3
|
6.2 ± 1.1
|
2.8 ± 0.8
|
G allele
| |
1.4 ± 0.3
|
6.1 ± 1.1
|
2.8 ± 0.7
|
P value
| |
0.18
|
0.60
|
0.68
|
(rs7412- rs429358) E2, E3, and E4
|
E3
| |
1.4 ± 0.4
|
6.2 ± 1.1
|
2.8 ± 0.8
|
E4
| |
1.4 ± 0.3
|
6.4 ± 1.1
|
3.0 ± 0.9
|
E2
| |
1.3 ± 0.3
|
5.8 ± 1.3
|
2.4 ± 0.8
|
P value
| |
0.95
|
2X10−6
|
4X10−4
|
- Values are given as mean ± SD. P values for differences between genotypes were obtained using linear regression model adjusted for age, sex, body mass index, and country
- Bonferroni corrected P value < 0.003 was considered statistically significant
- MAF minor allele frequency, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol
- a LDL-C values available only in Caerphilly prospective study