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Table 3 Association of APOE and LPL SNPs with HDL-C and total cholesterol levels in the PRECISE and Caerphilly studies

From: Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors

SNP MAF HDL-C (mmol/L) Total Cholesterol (mmol/L) LDL-C a (mmol/L)
PRECISE
LPL
 rs320 0.26    
 TT   1.6 ± 0.3 5.9 ± 1.1  
 T/G   1.7 ± 0.4 5.8 ± 1.0  
P value   0.02 0.19  
 rs328 0.10    
 CC   1.6 ± 0.3 5.9 ± 1.1  
 C/G   1.7 ± 0.4 5.7 ± 0.9  
P value   0.04 0.06  
APOE
 rs405509 0.47    
 GG   1.7 ± 0.4 5.8 ± 1.1  
 GT   1.5 ± 0.3 5.8 ± 1.1  
 TT   1.6 ± 0.3 6.1 ± 1.0  
P value   0.07 0.23  
 rs769450 0.39    
 GG   1.6 ± 0.3 5.9 ± 1.1  
 A allele   1.6 ± 0.4 5.9 ± 1.1  
P value   0.72 0.97  
 rs439401 0.33    
 CC   1.6 ± 0.4 5.9 ± 1.1  
 T allele   1.6 ± 0.3 5.9 ± 1.1  
P value   0.43 0.51  
 rs445925 0.11    
 GG   1.6 ± 0.3 5.9 ± 1.1  
 A allele   1.7 ± 0.4 5.6 ± 0.9  
P value   0.25 0.003  
 rs405697 0.25    
 GG   1.6 ± 0.4 5.9 ± 1.1  
 A allele   1.6 ± 0.3 5.9 ± 1.0  
P value   0.71 0.96  
 rs1160985 0.43    
 CC   1.6 ± 0.3 5.9 ± 1.1  
 CT   1.6 ± 0.4 5.8 ± 1.0  
 TT   1.7 ± 0.4 5.9 ± 1.1  
P value   0.12 0.44  
 rs1064725 0.04    
 TT   1.6 ± 0.4 5.9 ± 1.0  
 G allele   1.7 ± 0.3 6.1 ± 1.2  
P value   0.17 0.38  
 (rs7412- rs429358) E2, E3, and E4
 E3   1.6 ± 0.3 5.9 ± 1.1  
 E4   1.5 ± 0.3 6.1 ± 1.1  
 E2   1.7 ± 0.4 5.5 ± 0.9  
P value   0.09 4X10−4  
Caerphilly
LPL
 rs320 0.26    
 TT   1.3 ± 0.3 6.1 ± 1.1 2.7 ± 0.8
 T/G   1.4 ± 0.3 6.2 ± 1.2 2.8 ± 0.8
P value   0.05 0.55 0.05
 rs328 0.10    
 CC   1.3 ± 0.3 6.1 ± 1.1 2.7 ± 0.8
 C/G   1.3 ± 0.3 6.1 ± 1.1 2.9 ± 0.9
P value   0.63 0.71 0.05
APOE
 rs405509 0.46    
 GG   1.4 ± 0.3 6.0 ± 1.1 2.7 ± 0.9
 GT   1.3 ± 0.3 6.2 ± 1.1 2.8 ± 0.8
 TT   1.3 ± 0.3 6.3 ± 1.1 2.9 ± 0.9
P value   0.16 0.02 0.29
 rs769450 0.41    
 GG   1.3 ± 0.2 6.1 ± 1.2 2.8 ± 0.9
 A allele   1.4 ± 0.3 6.2 ± 1.1 2.8 ± 0.8
P value   0.10 0.41 0.82
 rs439401 0.35    
 CC   1.4 ± 0.3 6.2 ± 1.1 2.8 ± 0.9
 T allele   1.3 ± 0.3 6.1 ± 1.1 2.7 ± 0.8
P value   0.72 0.42 0.32
 rs445925 0.11    
 GG   1.3 ± 0.3 6.2 ± 1.1 2.8 ± 0.8
 A allele   1.3 ± 0.3 5.9 ± 1.2 2.5 ± 0.9
P value   0.99 3X10−4 0.001
 rs405697 0.26    
 GG   1.4 ± 0.4 6.1 ± 1.1 2.8 ± 0.9
 A allele   1.3 ± 0.3 6.1 ± 1.1 2.8 ± 0.8
P value   0.30 0.88 0.9
 rs1160985 0.45    
 CC   1.34 ± 0.29 6.2 ± 1.1 2.8 ± 0.9
 CT   1.35 ± 0.35 6.2 ± 1.2 2.7 ± 0.8
 TT   1.37 ± 0.40 6.1 ± 1.0 2.8 ± 0.8
P value   0.61 0.30 0.73
 rs1064725 0.01    
 TT   1.3 ± 0.3 6.2 ± 1.1 2.8 ± 0.8
 G allele   1.4 ± 0.3 6.1 ± 1.1 2.8 ± 0.7
P value   0.18 0.60 0.68
(rs7412- rs429358) E2, E3, and E4
 E3   1.4 ± 0.4 6.2 ± 1.1 2.8 ± 0.8
 E4   1.4 ± 0.3 6.4 ± 1.1 3.0 ± 0.9
 E2   1.3 ± 0.3 5.8 ± 1.3 2.4 ± 0.8
P value   0.95 2X10−6 4X10−4
  1. Values are given as mean ± SD. P values for differences between genotypes were obtained using linear regression model adjusted for age, sex, body mass index, and country
  2. Bonferroni corrected P value < 0.003 was considered statistically significant
  3. MAF minor allele frequency, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol
  4. a LDL-C values available only in Caerphilly prospective study