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Table 3 Association of APOE and LPL SNPs with HDL-C and total cholesterol levels in the PRECISE and Caerphilly studies

From: Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors

SNP

MAF

HDL-C (mmol/L)

Total Cholesterol (mmol/L)

LDL-C a (mmol/L)

PRECISE

LPL

 rs320

0.26

   

 TT

 

1.6 ± 0.3

5.9 ± 1.1

 

 T/G

 

1.7 ± 0.4

5.8 ± 1.0

 

 P value

 

0.02

0.19

 

 rs328

0.10

   

 CC

 

1.6 ± 0.3

5.9 ± 1.1

 

 C/G

 

1.7 ± 0.4

5.7 ± 0.9

 

 P value

 

0.04

0.06

 

APOE

 rs405509

0.47

   

 GG

 

1.7 ± 0.4

5.8 ± 1.1

 

 GT

 

1.5 ± 0.3

5.8 ± 1.1

 

 TT

 

1.6 ± 0.3

6.1 ± 1.0

 

 P value

 

0.07

0.23

 

 rs769450

0.39

   

 GG

 

1.6 ± 0.3

5.9 ± 1.1

 

 A allele

 

1.6 ± 0.4

5.9 ± 1.1

 

 P value

 

0.72

0.97

 

 rs439401

0.33

   

 CC

 

1.6 ± 0.4

5.9 ± 1.1

 

 T allele

 

1.6 ± 0.3

5.9 ± 1.1

 

 P value

 

0.43

0.51

 

 rs445925

0.11

   

 GG

 

1.6 ± 0.3

5.9 ± 1.1

 

 A allele

 

1.7 ± 0.4

5.6 ± 0.9

 

 P value

 

0.25

0.003

 

 rs405697

0.25

   

 GG

 

1.6 ± 0.4

5.9 ± 1.1

 

 A allele

 

1.6 ± 0.3

5.9 ± 1.0

 

 P value

 

0.71

0.96

 

 rs1160985

0.43

   

 CC

 

1.6 ± 0.3

5.9 ± 1.1

 

 CT

 

1.6 ± 0.4

5.8 ± 1.0

 

 TT

 

1.7 ± 0.4

5.9 ± 1.1

 

 P value

 

0.12

0.44

 

 rs1064725

0.04

   

 TT

 

1.6 ± 0.4

5.9 ± 1.0

 

 G allele

 

1.7 ± 0.3

6.1 ± 1.2

 

 P value

 

0.17

0.38

 

 (rs7412- rs429358) E2, E3, and E4

 E3

 

1.6 ± 0.3

5.9 ± 1.1

 

 E4

 

1.5 ± 0.3

6.1 ± 1.1

 

 E2

 

1.7 ± 0.4

5.5 ± 0.9

 

 P value

 

0.09

4X10−4

 

Caerphilly

 LPL

 rs320

0.26

   

 TT

 

1.3 ± 0.3

6.1 ± 1.1

2.7 ± 0.8

 T/G

 

1.4 ± 0.3

6.2 ± 1.2

2.8 ± 0.8

 P value

 

0.05

0.55

0.05

 rs328

0.10

   

 CC

 

1.3 ± 0.3

6.1 ± 1.1

2.7 ± 0.8

 C/G

 

1.3 ± 0.3

6.1 ± 1.1

2.9 ± 0.9

 P value

 

0.63

0.71

0.05

APOE

 rs405509

0.46

   

 GG

 

1.4 ± 0.3

6.0 ± 1.1

2.7 ± 0.9

 GT

 

1.3 ± 0.3

6.2 ± 1.1

2.8 ± 0.8

 TT

 

1.3 ± 0.3

6.3 ± 1.1

2.9 ± 0.9

 P value

 

0.16

0.02

0.29

 rs769450

0.41

   

 GG

 

1.3 ± 0.2

6.1 ± 1.2

2.8 ± 0.9

 A allele

 

1.4 ± 0.3

6.2 ± 1.1

2.8 ± 0.8

 P value

 

0.10

0.41

0.82

 rs439401

0.35

   

 CC

 

1.4 ± 0.3

6.2 ± 1.1

2.8 ± 0.9

 T allele

 

1.3 ± 0.3

6.1 ± 1.1

2.7 ± 0.8

 P value

 

0.72

0.42

0.32

 rs445925

0.11

   

 GG

 

1.3 ± 0.3

6.2 ± 1.1

2.8 ± 0.8

 A allele

 

1.3 ± 0.3

5.9 ± 1.2

2.5 ± 0.9

 P value

 

0.99

3X10−4

0.001

 rs405697

0.26

   

 GG

 

1.4 ± 0.4

6.1 ± 1.1

2.8 ± 0.9

 A allele

 

1.3 ± 0.3

6.1 ± 1.1

2.8 ± 0.8

 P value

 

0.30

0.88

0.9

 rs1160985

0.45

   

 CC

 

1.34 ± 0.29

6.2 ± 1.1

2.8 ± 0.9

 CT

 

1.35 ± 0.35

6.2 ± 1.2

2.7 ± 0.8

 TT

 

1.37 ± 0.40

6.1 ± 1.0

2.8 ± 0.8

 P value

 

0.61

0.30

0.73

 rs1064725

0.01

   

 TT

 

1.3 ± 0.3

6.2 ± 1.1

2.8 ± 0.8

 G allele

 

1.4 ± 0.3

6.1 ± 1.1

2.8 ± 0.7

 P value

 

0.18

0.60

0.68

(rs7412- rs429358) E2, E3, and E4

 E3

 

1.4 ± 0.4

6.2 ± 1.1

2.8 ± 0.8

 E4

 

1.4 ± 0.3

6.4 ± 1.1

3.0 ± 0.9

 E2

 

1.3 ± 0.3

5.8 ± 1.3

2.4 ± 0.8

 P value

 

0.95

2X10−6

4X10−4

  1. Values are given as mean ± SD. P values for differences between genotypes were obtained using linear regression model adjusted for age, sex, body mass index, and country
  2. Bonferroni corrected P value < 0.003 was considered statistically significant
  3. MAF minor allele frequency, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol
  4. a LDL-C values available only in Caerphilly prospective study