SNP | MAF | HDL-C (mmol/L) | Total Cholesterol (mmol/L) | LDL-C a (mmol/L) |
---|---|---|---|---|
PRECISE | ||||
LPL | ||||
 rs320 | 0.26 |  |  |  |
 TT |  | 1.6 ± 0.3 | 5.9 ± 1.1 |  |
 T/G |  | 1.7 ± 0.4 | 5.8 ± 1.0 |  |
 P value |  | 0.02 | 0.19 |  |
 rs328 | 0.10 |  |  |  |
 CC |  | 1.6 ± 0.3 | 5.9 ± 1.1 |  |
 C/G |  | 1.7 ± 0.4 | 5.7 ± 0.9 |  |
 P value |  | 0.04 | 0.06 |  |
APOE | ||||
 rs405509 | 0.47 |  |  |  |
 GG |  | 1.7 ± 0.4 | 5.8 ± 1.1 |  |
 GT |  | 1.5 ± 0.3 | 5.8 ± 1.1 |  |
 TT |  | 1.6 ± 0.3 | 6.1 ± 1.0 |  |
 P value |  | 0.07 | 0.23 |  |
 rs769450 | 0.39 |  |  |  |
 GG |  | 1.6 ± 0.3 | 5.9 ± 1.1 |  |
 A allele |  | 1.6 ± 0.4 | 5.9 ± 1.1 |  |
 P value |  | 0.72 | 0.97 |  |
 rs439401 | 0.33 |  |  |  |
 CC |  | 1.6 ± 0.4 | 5.9 ± 1.1 |  |
 T allele |  | 1.6 ± 0.3 | 5.9 ± 1.1 |  |
 P value |  | 0.43 | 0.51 |  |
 rs445925 | 0.11 |  |  |  |
 GG |  | 1.6 ± 0.3 | 5.9 ± 1.1 |  |
 A allele |  | 1.7 ± 0.4 | 5.6 ± 0.9 |  |
 P value |  | 0.25 | 0.003 |  |
 rs405697 | 0.25 |  |  |  |
 GG |  | 1.6 ± 0.4 | 5.9 ± 1.1 |  |
 A allele |  | 1.6 ± 0.3 | 5.9 ± 1.0 |  |
 P value |  | 0.71 | 0.96 |  |
 rs1160985 | 0.43 |  |  |  |
 CC |  | 1.6 ± 0.3 | 5.9 ± 1.1 |  |
 CT |  | 1.6 ± 0.4 | 5.8 ± 1.0 |  |
 TT |  | 1.7 ± 0.4 | 5.9 ± 1.1 |  |
 P value |  | 0.12 | 0.44 |  |
 rs1064725 | 0.04 |  |  |  |
 TT |  | 1.6 ± 0.4 | 5.9 ± 1.0 |  |
 G allele |  | 1.7 ± 0.3 | 6.1 ± 1.2 |  |
 P value |  | 0.17 | 0.38 |  |
 (rs7412- rs429358) E2, E3, and E4 | ||||
 E3 |  | 1.6 ± 0.3 | 5.9 ± 1.1 |  |
 E4 |  | 1.5 ± 0.3 | 6.1 ± 1.1 |  |
 E2 |  | 1.7 ± 0.4 | 5.5 ± 0.9 |  |
 P value |  | 0.09 | 4X10−4 |  |
Caerphilly | ||||
 LPL | ||||
 rs320 | 0.26 |  |  |  |
 TT |  | 1.3 ± 0.3 | 6.1 ± 1.1 | 2.7 ± 0.8 |
 T/G |  | 1.4 ± 0.3 | 6.2 ± 1.2 | 2.8 ± 0.8 |
 P value |  | 0.05 | 0.55 | 0.05 |
 rs328 | 0.10 |  |  |  |
 CC |  | 1.3 ± 0.3 | 6.1 ± 1.1 | 2.7 ± 0.8 |
 C/G |  | 1.3 ± 0.3 | 6.1 ± 1.1 | 2.9 ± 0.9 |
 P value |  | 0.63 | 0.71 | 0.05 |
APOE | ||||
 rs405509 | 0.46 |  |  |  |
 GG |  | 1.4 ± 0.3 | 6.0 ± 1.1 | 2.7 ± 0.9 |
 GT |  | 1.3 ± 0.3 | 6.2 ± 1.1 | 2.8 ± 0.8 |
 TT |  | 1.3 ± 0.3 | 6.3 ± 1.1 | 2.9 ± 0.9 |
 P value |  | 0.16 | 0.02 | 0.29 |
 rs769450 | 0.41 |  |  |  |
 GG |  | 1.3 ± 0.2 | 6.1 ± 1.2 | 2.8 ± 0.9 |
 A allele |  | 1.4 ± 0.3 | 6.2 ± 1.1 | 2.8 ± 0.8 |
 P value |  | 0.10 | 0.41 | 0.82 |
 rs439401 | 0.35 |  |  |  |
 CC |  | 1.4 ± 0.3 | 6.2 ± 1.1 | 2.8 ± 0.9 |
 T allele |  | 1.3 ± 0.3 | 6.1 ± 1.1 | 2.7 ± 0.8 |
 P value |  | 0.72 | 0.42 | 0.32 |
 rs445925 | 0.11 |  |  |  |
 GG |  | 1.3 ± 0.3 | 6.2 ± 1.1 | 2.8 ± 0.8 |
 A allele |  | 1.3 ± 0.3 | 5.9 ± 1.2 | 2.5 ± 0.9 |
 P value |  | 0.99 | 3X10−4 | 0.001 |
 rs405697 | 0.26 |  |  |  |
 GG |  | 1.4 ± 0.4 | 6.1 ± 1.1 | 2.8 ± 0.9 |
 A allele |  | 1.3 ± 0.3 | 6.1 ± 1.1 | 2.8 ± 0.8 |
 P value |  | 0.30 | 0.88 | 0.9 |
 rs1160985 | 0.45 |  |  |  |
 CC |  | 1.34 ± 0.29 | 6.2 ± 1.1 | 2.8 ± 0.9 |
 CT |  | 1.35 ± 0.35 | 6.2 ± 1.2 | 2.7 ± 0.8 |
 TT |  | 1.37 ± 0.40 | 6.1 ± 1.0 | 2.8 ± 0.8 |
 P value |  | 0.61 | 0.30 | 0.73 |
 rs1064725 | 0.01 |  |  |  |
 TT |  | 1.3 ± 0.3 | 6.2 ± 1.1 | 2.8 ± 0.8 |
 G allele |  | 1.4 ± 0.3 | 6.1 ± 1.1 | 2.8 ± 0.7 |
 P value |  | 0.18 | 0.60 | 0.68 |
(rs7412- rs429358) E2, E3, and E4 | ||||
 E3 |  | 1.4 ± 0.4 | 6.2 ± 1.1 | 2.8 ± 0.8 |
 E4 |  | 1.4 ± 0.3 | 6.4 ± 1.1 | 3.0 ± 0.9 |
 E2 |  | 1.3 ± 0.3 | 5.8 ± 1.3 | 2.4 ± 0.8 |
 P value |  | 0.95 | 2X10−6 | 4X10−4 |