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Table 4 Interaction between APOE and LPL SNPs and dietary factors on HDL-C and total cholesterol in the PRECISE study

From: Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors

Interaction between rs320 at LPL*dietary factors on HDL-C
Interaction between SNP rs320* fat energy % intake Interaction between SNP rs320* protein energy % intake Interaction between SNP rs320* carbohydrate energy % intake
0.003 (0.004)
0.46
0.002 (0.01)
0.76
−0.0004 (0.002)
0.87
Interaction between rs320 at LPL *dietary factors on Total Cholesterol
Interaction between SNP rs320* fat energy % intake Interaction between SNP rs320* protein energy % intake Interaction between SNP rs320* carbohydrate energy % intake
0.01(0.01)
0.27
−0.03 (0.02)
0.13
−0.01 (0.01)
0.06
Interaction between rs328 at LPL *dietary factors on HDL-C
Interaction between SNP rs328* fat energy % intake Interaction between SNP rs328* protein energy % intake Interaction between SNP rs328* carbohydrate energy % intake
0.01 (0.01)
0.09
−0.001 (0.01)
0.89
0.001 (0.003)
0.63
Interaction between rs328 at LPL *dietary factors on Total Cholesterol
Interaction between SNP rs328* fat energy % intake Interaction between SNP rs328* protein energy % intake Interaction between SNP rs328* carbohydrate energy % intake
−0.002 (0.02)
0.88
0.003 (0.03)
0.90
−0.01 (0.01)
0.55
Interaction between rs405509 at APOE*dietary factors on HDL-C
Interaction between SNP rs405509* fat energy % intake Interaction between SNP rs405509* protein energy % intake Interaction between SNP rs405509* carbohydrate energy % intake
0.01 (0.01)
0.11
−0.001 (0.01)
0.75
−0.01 (0.003)
0.09
Interaction between rs405509 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs405509* fat energy % intake Interaction between SNP rs405509* protein energy % intake Interaction between SNP rs405509* carbohydrate energy % intake
0.02 (0.02)
0.39
−0.04 (0.03)
0.26
−0.01 (0.01)
0.59
Interaction between rs769450 at APOE *dietary factors on HDL-C
Interaction between SNP rs769450* fat energy % intake Interaction between SNP rs769450* protein energy % intake Interaction between SNP rs769450* carbohydrate energy % intake
−0.001 (0.004)
0.88
0.001 (0.01)
0.88
0.003 (0.003)
0.19
Interaction between rs769450 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs769450* fat energy % intake Interaction between SNP rs769450* protein energy % intake Interaction between SNP rs769450* carbohydrate energy % intake
−0.001 (0.01)
0.94
0.01 (0.02)
0.63
0.01 (0.01)
0.51
Interaction between rs439401 at APOE *dietary factors on HDL-C
Interaction between SNP rs439401* fat energy % intake Interaction between SNP rs439401* protein energy % intake Interaction between SNP rs439401* carbohydrate energy % intake
0.01 (0.004)
0.11
0.01 (0.01)
0.39
−0.001 (0.003)
0.64
Interaction between rs439401 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs439401* fat energy % intake Interaction between SNP rs439401* protein energy % intake Interaction between SNP rs439401* carbohydrate energy % intake
0.003 (0.01)
0.79
−0.02 (0.02)
0.37
− 0.001 (0.01)
0.89
Interaction between rs445925 at APOE *dietary factors on HDL-C
Interaction between SNP rs445925* fat energy % intake Interaction between SNP rs445925* protein energy % intake Interaction between SNP rs445925* carbohydrate energy % intake
−0.003 (0.01)
0.53
0.01 (0.01)
0.52
0.0003 (0.003)
0.93
Interaction between rs445925 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs445925* fat energy % intake Interaction between SNP rs445925* protein energy % intake Interaction between SNP rs445925* carbohydrate energy % intake
−0.03 (0.01)
0.05
0.01 (0.03)
0.66
0.01 (0.01)
0.36
Interaction between rs405697 at APOE *dietary factors on HDL-C
Interaction between SNP rs405697* fat energy % intake Interaction between SNP rs405697* protein energy % intake Interaction between SNP rs405697* carbohydrate energy % intake
0.01(0.004)
0.06
−0.002 (0.01)
0.80
−0.004 (0.002)
0.16
Interaction between rs405697 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs405697* fat energy % intake Interaction between SNP rs405697* protein energy % intake Interaction between SNP rs405697* carbohydrate energy % intake
0.01 (0.01)
0.22
−0.03 (0.02)
0.19
−0.003 (0.01)
0.72
Interaction between rs1160985 at APOE *dietary factors on HDL-C
Interaction between SNP rs1160985* fat energy % intake Interaction between SNP rs1160985* protein energy % intake Interaction between SNP rs1160985* carbohydrate energy % intake
−0.01 (0.01)
0.08
−0.002 (0.01)
0.97
0.01 (0.004)
0.03
Interaction between rs1160985 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs1160985* fat energy % intake Interaction between SNP rs1160985* protein energy % intake Interaction between SNP rs1160985* carbohydrate energy % intake
−0.01 (0.01)
0.58
0.05 (0.03)
0.28
−0.001 (0.01)
0.19
Interaction between rs1064725 at APOE *dietary factors on HDL-C
Interaction between SNP rs1064725* fat energy % intake Interaction between SNP rs1064725* protein energy % intake Interaction between SNP rs1064725* carbohydrate energy % intake
−0.001 (0.01)
0.90
0.004 (0.02)
0.77
−0.002 (0.004)
0.73
Interaction between rs1064725 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs1064725* fat energy % intake Interaction between SNP rs1064725* protein energy % intake Interaction between SNP rs1064725* carbohydrate energy % intake
0.03 (0.03)
0.28
0.02 (0.04)
0.62
−0.01 (0.01)
0.48
Interaction between APOE (E2, E3, and E4)*dietary factors on HDL-C
Interaction between SNP APOE (E2, E3, and E4)* fat energy % intake Interaction between SNP APOE (E2, E3, and E4)* protein energy % intake Interaction between SNP APOE (E2, E3, and E4)* carbohydrate energy % intake
−0.01 (0.01)
0.39
0.001 (0.01)
0.99
0.002 (0.003)
0.17
Interaction between APOE (E2, E3, and E4)*dietary factors on Total Cholesterol
Interaction between SNP APOE (E2, E3, and E4)* fat energy % intake Interaction between SNP APOE (E2, E3, and E4)* protein energy % intake Interaction between SNP APOE (E2, E3, and E4)* carbohydrate energy % intake
−0.03 (0.02)
0.18
−0.02 (0.04)
0.32
0.01 (0.01)
0.51
  1. Values represented β regression coefficients (± S.E), and Pinteraction. P values were obtained by using a general linear model adjusted for age, sex, body mass index, country and total energy intake, wherever appropriate
  2. Bonferroni corrected P value < 0.001 was considered statistically significant
  3. HDL-C High density lipoprotein cholesterol