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Table 5 Interaction between APOE and LPL SNPs and dietary factors on total cholesterol in the CaPS

From: Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors

Interaction between rs320 at LPL *dietary factors on Total Cholesterol
Interaction between SNP rs320* fat energy % intake Interaction between SNP rs320* protein energy % intake Interaction between SNP rs320* carbohydrate energy % intake
0.01 (0.01)
0.48
− 0.01 (0.03)
0.57
− 0.004 (0.01)
0.64
Interaction between rs328 at LPL *dietary factors on Total Cholesterol
Interaction between SNP rs328* fat energy % intake Interaction between SNP rs328* protein energy % intake Interaction between SNP rs328* carbohydrate energy % intake
− 0.01 (0.01)
0.58
−0.04 (0.03)
0.17
0.01 (0.01)
0.29
Interaction between rs405509 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs405509* fat energy % intake Interaction between SNP rs405509* protein energy % intake Interaction between SNP rs405509* carbohydrate energy % intake
0.03 (0.01)
0.11
−0.04 (0.04)
0.52
−0.02 (0.01)
0.31
Interaction between rs769450 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs769450* fat energy % intake Interaction between SNP rs769450* protein energy % intake Interaction between SNP rs769450* carbohydrate energy % intake
−0.01 (0.01)
0.10
0.05 (0.02)
0.04
0.01 (0.01)
0.42
Interaction between rs439401 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs439401* fat energy % intake Interaction between SNP rs439401* protein energy % intake Interaction between SNP rs439401* carbohydrate energy % intake
−0.003 (0.01)
0.77
−0.01 (0.03)
0.68
0.004 (0.01)
0.65
Interaction between rs445925 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs445925* fat energy % intake Interaction between SNP rs445925* protein energy % intake Interaction between SNP rs445925* carbohydrate energy % intake
−0.0003 (0.01)
0.97
−0.02 (0.03)
0.55
0.002 (0.01)
0.87
Interaction between rs405697 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs405697* fat energy % intake Interaction between SNP rs405697* protein energy % intake Interaction between SNP rs405697* carbohydrate energy % intake
0.01 (0.01)
0.51
−0.03 (0.03)
0.24
−0.002 (0.01)
0.84
Interaction between rs1160985 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs1160985* fat energy % intake Interaction between SNP rs1160985* protein energy % intake Interaction between SNP rs1160985* carbohydrate energy % intake
−0.01 (0.01)
0.13
−0.004 (0.03)
0.19
0.01 (0.01)
0.43
Interaction between rs1064725 at APOE *dietary factors on Total Cholesterol
Interaction between SNP rs1064725* fat energy % intake Interaction between SNP rs1064725* protein energy % intake Interaction between SNP rs1064725* carbohydrate energy % intake
−0.01 (0.03)
0.66
0.05 (0.11)
0.62
0.01 (0.03)
0.74
Interaction between APOE (E2,E3, and E4)*dietary factors on Total Cholesterol
Interaction between SNP APOE (E2, E3, and E4)* fat energy % intake Interaction between SNP APOE (E2, E3, and E4)* protein energy % intake Interaction between SNP APOE (E2, E3, and E4)* carbohydrate energy % intake
−0.02 (0.02)
0.038
0.02 (0.04)
0.83
0.01 (0.01)
0.08
  1. Values represented β regression coefficients (± S.E), and Pinteraction
  2. P values were obtained by using a general linear model adjusted for age, sex, body mass index, country and total energy intake, wherever appropriate
  3. Bonferroni corrected P value < 0.001 was considered statistically significant