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Table 3 Overall and subgroup meta-analysis of the association between ADIPOQ rs2241766, +45 T > G polymorphisms and CVD

From: Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

Categories

n

Sample size

G VS T

GG + GT VS TT

GG VS GT + TT

GT VS TT

GG VS TT

Case/Control

OR (95% CI)

P

I2(%)/Ph

OR (95% CI)

P

I2(%)/Ph

OR (95% CI)

P

I2(%)/Ph

OR (95% CI)

P

I2(%)/Ph

OR (95% CI)

P

I2(%)/Ph

Overall

40

10,746/14,802

1.216 (1.102, 1.343)

< 0.001

72.4/0.000

1.229 (1.103, 1.369)

< 0.001

65.6/0.000

1.286 (1.061, 1.560)

0.011

49.7/0.000

1.172 (1.063, 1.292)

0.001

53.3/0.000

1.361 (1.095, 1.690)

0.005

57.7/0.000

Population

 European

12

4,452/7,255

1.067 (0.918, 1.242)

0.398

60.4/0.003

1.105 (0.937, 1.303)

0.238

58.3/0.006

0.779 (0.576, 1.055)

0.106

0.0/0.663

1.123 (0.956, 1.319)

0.157

53.0/0.015

0.792 (0.584, 1.073)

0.132

0.0/0.585

 East Asian

20

5,305/6,505

1.194 (1.057, 1.348)

0.004

70.5/0.000

1.225 (1.057, 1.420)

0.007

67.3/0.000

1.315 (1.068, 1.618)

0.010

43.1/0.024

1.180 (1.029, 1.353)

0.018

58.1/0.001

1.431 (1.112, 1.842)

0.005

58.6/0.001

 West Asian

  5

660/719

1.550 (1.002, 2.396)

0.049

80.8/0.000

1.392 (0.893, 2.170)

0.145

71.3/0.007

2.715 (1.452, 5.079)

0.002

50.2/0.091

1.099 (0.779, 1.549)

0.591

43.2/0.134

2.767 (1.347, 5.683)

0.006

59.2/0.044

 African

  3

329/323

2.200 (0.890, 5.437)

0.088

75.3/0.017

2.148 (0.952, 4.844)

0.066

65.2/0.056

2.010 (0.251, 16.080)

0.511

50.8/0.154

1.919 (0.998, 3.688)

0.051

45.1/0.162

2.295 (0.250, 21.058)

0.463

55.2/0.135

Genotyping

 PCR-RFLP

20

4,814/6,319

1.242 (1.055, 1.462)

0.009

77.1/0.000

1.279 (1.057, 1.548)

0.012

74.4/0.000

1.335 (1.034, 1.722)

0.027

40.5/0.035

1.221 (1.023, 1.458)

0.027

67.0/0.000

1.442 (1.054, 1.975)

0.022

57.1/0.001

 TaqMan

  7

2,616/3,715

1.087 (0.895, 1.320)

0.400

64.8/0.009

1.118 (0.920, 1.357)

0.262

53.9/0.043

0.872 (0.513, 1.482)

0.614

56.9/0.041

1.123 (0.951, 1.326)

0.172

34.9/0.162

0.896 (0.506, 1.588)

0.708

62.2/0.021

 Other

13

3,316/4,768

1.263 (1.075, 1.485)

0.005

68.7/0.000

1.238 (1.056, 1.452)

0.009

51.4/0.016

1.453 (1.021, 2.066)

0.038

56.7/0.006

1.150 (1.004, 1.317)

0.044

27.6/0.166

1.522 (1.056, 2.193)

0.024

57.7/0.005

Sample size

  < 1000

34

7,651/6,381

1.298 (1.164, 1.448)

< 0.001

66.6/0.000

1.317 (1.163, 1.492)

< 0.001

61.1/0.000

1.512 (1.264, 1.809)

< 0.001

25.5/0.096

1.239 (1.102, 1.393)

< 0.001

51.4/0.000

1.620 (1.324, 1.981)

< 0.001

35.9/0.024

  ≥ 1000

  6

3,095/8,421

0.920 (0.834, 1.015)

0.097

23.9/0.255

0.945 (0.841, 1.062)

0.344

25.5/0.243

0.690 (0.539, 0.885)

0.003

0.0/0.758

0.981 (0.879, 1.094)

0.728

11.3/0.343

0.669 (0.519, 0.862)

0.002

0.0/0.661

Quality score

  < 10

26

5,467/4,951

1.366 (1.176, 1.586)

< 0.001

77.0/0.000

1.404 (1.183, 1.667)

< 0.001

72.8/0.000

1.529 (1.202, 1.944)

0.001

46.0/0.008

1.314 (1.121, 1.539)

0.001

64.4/0.000

1.692 (1.274, 2.248)

< 0.001

58.4/0.000

  ≥ 10

14

5,279/9,851

1.036 (0.944, 1.139)

0.455

37.3/0.079

1.038 (0.955, 1.128)

0.376

0.0/0.575

0.978 (0.719, 1.331)

0.887

49.9/0.017

1.043 (0.956, 1.137)

0.343

0.0/0.818

0.985 (0.725, 1.340)

0.925

47.5/0.025

  1. n study numbers; Bold values represent statistically significant findings