Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

Kanu, Joseph Sam; Qiu, Shuang; Cheng, Yi; Li, Ri; Kou, Changgui; Gu, Yulu; Bai, Ye; Shi, Jikang; Li, Yong; Liu, Yunkai; Yu, Yaqin; Liu, Yawen

doi:10.1186/s12944-018-0767-8

Lipids in Health and Disease

Table 4 Overall and subgroup meta-analysis of the association between ADIPOQ rs1501299, +276 G > T polymorphism and CVD

From: Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

Categories	n	Sample size	T VS G			TT + TG VS GG			TT VS TG + GG			TG VS GG			TT VS GG
Categories	n	Case/Control	OR (95%CI)	P	I²⁽%)/Ph	OR (95%CI)	P	I²⁽%)/Ph	OR (95%CI)	P	I²⁽%)/Ph	OR (95%CI)	P	I²⁽%)/Ph	OR (95%CI)	P	I²⁽%)/Ph
Overall	44	12,852/24,519	0.956 (0.893, 1.023)	0.189	64.7/0.000	0.967 (0.890, 1.051)	0.431	60.6/0.000	0.899 (0.797, 1.015)	0.086	42.0/0.002	0.987 (0.913, 1.066)	0.737	49.2/0.000	0.886 (0.766, 1.025)	0.104	55.5/0.000
Population
European	18	7,002/11,337	0.957 (0.901, 1.016)	0.146	16.2/0.260	0.967 (0.896, 1.043)	0.380	16.1/0.262	0.851 (0.717, 1.011)	0.066	35.2/0.070	0.988 (0.909, 1.073)	0.773	21.3/0.201	0.854 (0.722, 1.012)	0.068	30.2/0.110
East Asian	20	5,107/12,291	0.966 (0.849, 1.098)	0.594	77.5/0.000	0.977 (0.834, 1.145)	0.776	74.4/0.000	0.945 (0.778, 1.149)	0.572	52.2/0.004	0.988 (0.858, 1.138)	0.867	64.0/0.000	0.940 (0.726, 1.217)	0.638	69.0/0.000
West Asian	4	479/645	0.973 (0.643, 1.473)	0.897	79.6/0.002	0.960 (0.564, 1.635)	0.880	77.8/0.004	0.999 (0.578, 1.727)	0.997	41.9/0.160	0.952 (0.587, 1.546)	0.843	70.2/0.018	0.986 (0.477, 2.040)	0.970	62.1/0.048
African	2	264/246	0.848 (0.629, 1.143)	0.278	11.8/0.287	0.856 (0.583, 1.257)	0.428	0.0/0.490	0.724 (0.415, 1.266)	0.258	7.8/0.298	0.927 (0.614, 1.400)	0.719	0.0/0.725	0.700 (0.374, 1.312)	0.266	14.7/0.279
Genotyping
PCR-RFLP	14	3,359/5,817	0.970 (0.833, 1.128)	0.688	74.2/0.000	0.997 (0.825, 1.206)	0.978	70.6/0.000	0.881 (0.684, 1.136)	0.329	55.3/0.006	1.051 (0.858, 1.202)	0.861	58.4/0.003	0.901 (0.648, 1.253)	0.535	68.4/0.000
TaqMan	13	3,666/6,001	0.977 (0.869, 1.099)	0.701	61.3/0.002	0.987 (0.854, 1.140)	0.859	58.0/0.005	0.970 (0.791, 1.189)	0.771	30.1/0.144	1.001 (0.874, 1.146)	0.994	47.8/0.028	0.956 (0.749, 1.221)	0.718	46.8/0.032
Others	17	5,827/12,701	0.930 (0.841, 1.029)	0.159	59.7/0.001	0.935 (0.827, 1.058)	0.287	55.1/0.003	0.866 (0.715, 1.048)	0.140	40.9/0.041	0.959 (0.852, 1.079)	0.484	46.3/0.019	0.841 (0.678, 1.044)	0.117	49.6/0.011
Sample size
< 1000	36	8,167/9,201	0.945 (0.868, 1.029)	0.191	64.8/0.000	0.959 (0.864, 1.065)	0.438	60.2/0.000	0.876 (0.756, 1.016)	0.079	41.8/0.005	0.985 (0.895, 1.085)	0.758	47.8/0.001	0.865 (0.722, 1.036)	0.116	56.0/0.000
≥ 1000	8	4,685/15,318	0.984 (0.877, 1.104)	0.784	68.6/0.002	0.985 (0.855, 1.134)	0.831	66.7/0.004	0.968 (0.784, 1.195)	0.762	44.8/0.080	0.987 (0.863, 1.129)	0.853	59.7/0.015	0.955 (0.748, 1.219)	0.711	56.3/0.025
Quality score
< 10	24	4,690/5,424	0.954 (0.848, 1.074)	0.438	69.1/0.000	0.976 (0.842, 1.132)	0.752	65.3/0.000	0.879 (0.725, 1.065)	0.189	41.7/0.018	1.002 (0.876, 1.145)	0.981	52.8/0.001	0.876 (0.683, 1.122)	0.294	59.3/0.000
≥ 10	20	8,162/19,095	0.959 (0.886, 1.038/)	0.298	60.0/0.000	0.963 (0.875, 1.060)	0.442	55.3/0.002	0.915 (0.782, 1.072)	0.273	44.7/0.017	0.976 (0.890, 1.070)	0.599	46.3/0.013	0.902 (0.756, 1.075)	0.250	52.2/0.004

Back to article page

ISSN: 1476-511X

Contact us

General enquiries: journalsubmissions@springernature.com