Fig. 3
From: Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice
Concentration–response curves of phenylephrine-induced contraction of aortic rings (a) and contraction in the presence of L-NNA (b). a The increase in contractions in KKAy-HF mice was not affected by chronic administration of EPA-E. b In the presence of L-NNA, the contractions induced by phenylephrine were increased in C57BL/6 J mice and reached levels found in KKAy-HF and KKAy-HF + EPA-E mice. Data are expressed as mean ± SEM; n = 6–8; **P < 0.01 ***P < 0.001 vs. C57BL/6 J