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Table 1 Characteristics of included studies

From: The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials

Authors (Ref) Publication year Sample size (control/intervention) Country/population Intervention (name and daily dose) Duration Presented data Age (y) (control, intervention) Results
Malvasi et al. [17] 2017 35/34 Italy/overweight pregnant 138 mg MI + 550 mg DCI 60 days TG, TC, LDL-C, HDL-C 32.31 ± 5.99, 32.35 ± 4.62 Decreased TC, LDL-C, HDL-C, TG
Cianci et al. [27] 2015 20/26 Italy/PCOS 1000 mg DCI + 600 mg a-lipoic acid 180 days TG, TC, HDL-C 23.8 ± 2.5 Increased HDL-C
Malvasi et al. [18] 2014 24/24 Italy/overweight pregnant 2000 mg MI + 400 mg DCI + 400 μg FA + 10 mg manganese 60 days TG, TC, LDL-C, HDL-C 31.58 ± 5.66, 32.2 ± 5.46 Decreased TC, LDL-C, HDL-C and TG
D’Anna et al. [24] 2014 24/26 Italy/postmenopausal women with MetS 2000 mg MI + 30 mg cocoa polyphenols + 80 mg soy isoflavones 6 months TG, HDL-C 55.5 ± 4.8, 56.3 ± 3.8 Decreased TG
Capasso et al. [25] 2013 78/77 Italy/postmenopausal women with MetS 4000 mg Inositol + a-lipoic acid 6 months TG, TC, HDL-C 58.2 ± 5.6, 57.71 ± 7.9 Decreased TG, increased HDL-C
Santamaria et al. [26] 2012 40/40 Italy/postmenopausal women with MetS 4000 mg MI (2 g b.i.d) 12 months TG, TC, HDL-C 55 ± 3.2, 55.6 ± 3.2 Decreased TG, TC, increased HDL-C
Giordano et al. [11] 2011 40/40 Italy/postmenopausal women with MetS 4000 mg MI (2 g b.i.d) 6 months TG, TC, HDL-C 55 ± 3.2, 55.6 ± 3.2 Decreased TG, TC, increased HDL-C
Minozzi et al. [28] 2011 75/80 Italy/PCOS 4000 mg MI + 400 μg FA + combined OCP 12 months TG, TC, LDL-C, HDL-C 29.4 ± 4.1, 28.8 ± 3.8 Decreased LDL-C, increased HDL-C
Costantino et al. [19] 2009 19/23 Italy/PCOS 4000 mg MI + 400 μg FA 12–16 weeks TG, TC 27.1 ± 1.4, 28.8 ± 1.5 Decreased TG, TC
Gerli et al. [20] 2007 47/45 Italy/PCOS 4000 mg MI + 400 μg FA 14 weeks TG, TC, LDL-C, HDL-C 29.7 CI [28.5–30.9], 29.0 CI [27.1–30.9] Increased HDL-C
Kim et al. [21] 2005 15/15 Republic of Korea/T2DM 1200 mg (600 mg twice) pinitol (D-3-O-methyl-Chiro-Inositol) 13 weeks TG, TC, LDL-C, HDL-C 61.7 ± 7.74, 59.9 ± 12 Decreased TC, LDL-C, Increased HDL-C
Gerli et al. [22] 2003 39/26 Italy/PCOS 200 mg (100 mg twice) inositol 14 weeks TG, TC, LDL-C, HDL-C 29.2 CI [27.5–30.7], 28.6 CI [26.9–30.3] Increased HDL-C
Iuorno et al. [16] 2002 10/10 Venezuela/PCOS 600 mg DCI 6–8 weeks TG, TC 26.5 ± 4.42, 28.2 ± 4.74 Decreased TG, TC
Nestler et al. [23] 1999 22/22 Venezuela/PCOS 1200 mg DCI 6–8 weeks TG, TC, LDL-C, HDL-C 26 ± 5, 29 ± 6 Decreased TG
  1. MI myo-inositol, DCI D-chiro-Inositol, FA folic acid, HDL-C high density lipoprotein-cholesterol, LDL-C low density lipoprotein-cholesterol, MetS metabolic syndrome, PCOS polycystic ovary syndrome, TC total cholesterol, TG triglycerides, T2DM type 2 diabetes mellitus