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Table 1 t-AUCB protected against ischemic arrhythmia inducibility in MI mice transfected with agomir-133

From: Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse model of myocardial infarction

Groups

VT

AF

sham(n = 6)

0

0

MI(n = 10)

7 (70%)*

2 (20%)

t-AUCB(0.1 mg/L) + sham(n = 6)

0

0

t-AUCB(0.1 mg/L) + MI(n = 10)

5 (50%)#

1(10%)

agomir-NC + MI(n = 6)

4 (67%)

1(17%)

agomir-133 + MI(n = 10)

9 (90%)#

1(10%)

agomir-133 + t-AUCB(0.1 mg/L) + MI(n = 5)

4 (80%)&

1 (20%)

  1. Data represent mean ± SEM
  2. Before the MI surgery or sham-operated, mice were randomized to receive either drinkingwater or t-AUCB (0.1 mg/L) for 1 week. Mice were transfected with agomir-NC or agomir133 (25 nM) via the tail vein after occlusion. Measurements were made 24 h after MI. Results in the table were incidence of inducible ventricular tachycardia
  3. VT ventricular tachycardia, AF atrial fibrillation
  4. *P<0.05 vs. sham group
  5. #P < 0.05 vs. MI group
  6. &P<0.05 vs agomir-133 + MI group, n = 5–10 for each group
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Lipids in Health and Disease

ISSN: 1476-511X