Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study

Table 2 Multivariate linear regression analysis of log-transformed ANGPTL8 and clinical variables

	Unadjusted Β 95%CI	P-Value	Model 1 Β 95% CI	P-Value	Model 2 Β 95% CI	P-Value
Non-HDL-C	0.042 (0.010–0.074)	0.011*	0.053 (0.023–0.083)	< 0.001**	0.050 (0.020–0.079)	< 0.001**
T1	Reference		Reference		Reference
T2	0.116 (0.025–0.207)	0.013*	0.112 (0.027–0.198)	0.010*	0.107 (0.025–0.189)	0.011*
T3	0.108 (0.023–0.194)	0.014*	0.239 (0.086–0.392)	0.002*	0.208 (0.060–0.357)	0.006*
Log-TG	0.279 (0.172–0.386)	< 0.001**	0.265 (0.156–0.375)	< 0.001**	0.271 (0.166–0.376)	< 0.001**
TC	0.028 (− 0.003–0.060)	0.081	0.044 (0.013–0.074)	0.005*	0.039 (0.009–0.068)	0.009*
HDL-C	−0.105 (− 0.199 - -0.011)	0.029*	− 0.104 (− 0.199 - -0.008)	0.033*	−0.108 (− 0.201 - -0.014)	0.024*
LDL-C	0.025 (−0.011–0.061)	0.176	0.042 (0.008–0.076)	0.016*	0.031 (− 0.002–0.064)	0.064

Tertile values of non-HDL-C are expressed as T1 (≤4.1 mmol/L), T2 (4.1–4.9 mmol/L), T3 (> 4.9 mmol/L)
Dependent variable: log-transformed ANGPTL8
Model 1: adjusted for age, gender and BMI
Model 2: adjusted for Model 1 + ALT, Hs-CRP,CR
Abbreviations: ANGPTL8 angiopoietin-like protein 8, CI confidence interval, HDL-C high-density lipoprotein cholesterol, TG triglycerides, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, BMI body mass index, ALT alanine aminotransferase, Hs-CRP High-sensitivity C-reactive protein, CR creatinine
*P < 0.05, **P < 0.001

ISSN: 1476-511X