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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients

Fig. 6

Effect on signal transducer and activators of transcription (STATs) signaling pathways in plasma of total mRNAs obtained from δ-tocotrienol treatment of hepatitis C patients. The STATs were down-regulated by δ-tocotrienol treatment, and belong to a family of cytoplasmic proteins with Src homology-2 (SH2) domains that acts as signal messenger and transcriptional factors and responses to cytokines and growth factors. The STAT pathways are activated via tyrosine phosphorylation cascade and play an important role in normal development of hematopoiesis, and regulates cancer metastasis by regulating the expression of genes that are critical to cell survival, cell proliferation, invasion, angiogenesis, and tumor immune evasion

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Lipids in Health and Disease

ISSN: 1476-511X