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Table 11 Effect of δ-tocotrienol on canonical pathways (33) of IPA ingenuity canonical pathways analysis (360) in hepatitis C patients

From: δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients

# Ingenuity Canonical Pathways (Fold Change Expression) -log (p-value) Ratio Z-Score Molecules
1 EIF2 Signaling; Eukaryotic translation initiation factors (221) 36.900 0.303 -5.692 RPL7A,EIF3G,RPL13A,RPL32,RPS24,RPL37A,RPL23,RPL26,RPS13
2 Regulation of eIF4 and p70S6K signaling (157) 13.300 0.210 0.000 PPP2R5E, EIF3G, RPS26
3 Protein ubiquitination pathway (265) 3.130 0.091 #NUM! UBE2J1, USP19, UBA52
4 mTOR signaling; Mammalian target of rapamycin (201) 12.900 0.184 -2.138 PPP2R5E, EIF3G, RPS26
5 Type I Diabetes Mellitus Signaling (111) 5.760 0.162 -2.496 NFKB1,MAP3K5,JAK2,HLA-DQB1,IFNGR2,TNFRSF1B,PIAS1,TRADD
6 Th1 and Th2 Activation Pathway (185) 5.640 0.130 #NUM! NFKB1,JAK2,NOTCH1,HLA-DQB1,IFNGR2,PIK3R1,HLA-DRA
7 Interferon Signaling (36) 4.700 0.250 -2.333 IFNGR1,OAS1,IFIT1,JAK2,IFITM1,IFNGR2,IFITM2,PIAS1,PSMB8
8 Role of IL-17F (44) 3.960 0.205 -3.000 NFKB1,ATF4,CREB1,RPS6KA3,CXCL1,MAPK1,CXCL8,RPS6KA4
9 IL-8 Signaling (197) 3.320 0.102 -4.123 NFKB1,GNA13,GNB4,RACK1,VEGFA,MYL12B,PIK3R1,ARRB2,NCF2
10 NF-κB Signaling (181) 2.940 0.099 -4.243 GSK3B,SIGIRR,NFKB1,CSNK2B,TNFRSF1B,IL1R2,PIK3R1,TRADD
11 IL-17A Signaling in Fibroblasts (35) 2.400 0.171 #NUM! GSK3B,NFKB1,CEBPD,CEBPB,MAPK1,TRAF6
12 IL-6 Signaling (128) 2.360 0.102 -3.051 NFKB1,JAK2,CSNK2B,TNFRSF1B,VEGFA,IL1R2,PIK3R1,CXCL8,FRS2
13 Induction of Apoptosis by HIV1 (61) 2.280 0.131 -2.828 CXCR4,NFKB1,MAP3K5,TNFRSF1B,CASP3,TRADD,RIPK1,SLC25A13
14 HMGB1 Signaling (133) 2.220 0.098 -3.606 OSM,NFKB1,IFNGR2,TNFRSF1B,PIK3R1,SP1,CXCL8,IFNGR1,HMGB1
15 PPAR Signaling (95) 2.040 0.105 1.897 NFKB1,TNFRSF1B,PTGS2,IL18RAP,MAPK1,IL1R2,HSP90AB1,SCAND1
16 IL-10 Signaling (69) 1.960 0.116 #NUM! NFKB1,IL18RAP,MAPK1,IL1R2,SP1,FCGR2A,TRAF6,IL10RA
17 iNOS Signaling (45) 1.860 0.133 -2.449 IFNGR1,NFKB1,JAK2,IFNGR2,MAPK1,TRAF6
18 Insulin Receptor Signaling (141) 1.650 0.085 -1.508 GSK3B,PPP1CC,PTEN,JAK2,GYS1,PDE3B,FRS2,MAPK1,GSK3A
19 p53 Signaling (111) 1.600 0.090 0.000 GSK3B,DRAM1,PTEN,HIF1A,FRS2,ATR,ST13,PIK3R1,PIAS1,PCNA
20 Role of IL-17A in Arthritis (69) 1.490 0.101 #NUM! NFKB1,FRS2,PTGS2,CXCL1,MAPK1,PIK3R1,CXCL8
21 Toll-like Receptor Signaling (76) 1.300 0.092 -1.000 SIGIRR,TLR8,UBA52,NFKB1,MAP3K1,MAPK1,TRAF6
22 IL-1 Signaling (92) 1.300 0.087 -2.449 GNAQ,NFKB1,GNA13,GNB4,RACK1,MAP3K1,MAPK1,TRAF6
23 Apoptosis Signaling (90) 0.987 0.078 -0.378 NFKB1,MAP3K5,BCL2L11,BCL2A1,TNFRSF1B,MAPK1,CASP3
24 PDGF Signaling (90) 0.987 0.078 -2.646 ABL1,JAK2,CSNK2B,MAP3K1,FRS2,MAPK1,PIK3R1
25 Type II Diabetes Mellitus Signaling (128) 0.944 0.070 -2.333 NFKB1,MAP3K5,TNFRSF1B,MAP3K1,FRS2,CEBPB,MAPK1,PIK3R1
26 IL-15 Signaling (76) 0.904 0.107 #NUM! NFKB1,JAK2,TXK
27 autophagy (62) 0.859 0.081 #NUM! CTSW,ATG3,ATG5,CTSC,LAMP2
28 IL-2 Signaling (64) 0.818 0.078 -2.000 CSNK2B,FRS2,MAPK1,PIK3R1,IL2RG
29 PPARα/RXRα Activation (180) 0.759 0.061 3.000 TGS1,GNAQ,TGFBR2,NFKB1,JAK2,IL18RAP,MAPK1,MED12,IL1R2
30 TNFR1 (32) 2.210 0.140 -2.646 NFKB1,MAP4K2,MAP3K1,PAK1,CASP3,TRADD,RIPK1
31 STAT3 Pathway (74) 0.641 0.068 -1.342 TGFBR2,JAK2,MAPK1,PTPN6,IGF2R
32 Nitric Oxide Signaling in the Cardiovascular System (113) 0.633 0.062 -2.646 ITPR2,VEGFA,PDE3B,FRS2,MAPK1,PIK3R1,HSP90AB1
33 Osteoarthritis Pathway (210) 3.370 0.100 -2.524 NFKB1,CREB1,NOTCH1,TNFRSF1B,VEGFA,KEF1,IL-1R2,mir-140