# | Master Regulator | Molecule Type | Part. regulators1 | Depth | Pred Acti State2 | Act. Z-Score3 | P-Value Over4 | Network Bi-Corr5 | Causal Net6 | Target-Con-Re7 |
---|---|---|---|---|---|---|---|---|---|---|
B | Down-regulation | |||||||||
25 | JAK1/2 | group | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -7.511 | 2.54E-14 | 0.0008 | 295 (81) | 80 |
26 | PPAR ligand-PPAR-Retinoic acid-RXRα | complex | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -4.459 | 3.31E-13 | 0.0131 | 306 (61) | 60 |
27 | LXR ligand-LXR-Retinoic acid-RXRα | complex | 26s Proteasome,Akt,AR | 3 | Inhibited | -4.815 | 4.17E-13 | 0.0085 | 290 (58) | 57 |
28 | PPARγ ligand-PPARγ-Retinoic acid-RARα | complex | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -4.230 | 4.23E-13 | 0.0121 | 306 (66) | 65 |
29 | PXR ligand-PXR-Retinoic acid-RXRα | complex | 26s Proteasome,AKT1 | 3 | Inhibited | -4.432 | 3.33E-12 | 0.0221 | 294 (58) | 58 |
30 | RAR ligand-RARα-Retinoic acid-RXRα | complex | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -5.396 | 3.52E-12 | 0.039 | 297 (57) | 56 |
31 | Vegf Receptor | group | 26s Proteasome,ABL1,Akt | 3 | Inhibited | -5.056 | 1.56E-11 | 0.0052 | 276 (93) | 90 |
32 | FXR ligand-FXR-Retinoic acid-RXRα | complex | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -5.100 | 1.96E-11 | 0.0484 | 291 (56) | 55 |
33 | hydrogen sulfide | chemical - endogenous mammalian | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -4.222 | 2.15E-11 | 0.0013 | 237 (92) | 89 |
34 | NLK | kinase | 26s Proteasome,AKT1,Alp | 3 | Inhibited | -3.429 | 8.72E-11 | 0.0375 | 248 (50) | 45 |
35 | CD80 | transmembrane receptor | CD28,CD80,IFNG,IL4 | 2 | Inhibited | -6.267 | 1.32E-10 | 0.003 | 132 (8) | 8 |
36 | Pdgfra-Pdgfrb | complex | 26s Proteasome,AKT1,AR | 3 | Inhibited | -7.878 | 1.37E-10 | 0.0184 | 285 (93) | 89 |
37 | Klra7 (includes others) | transmembrane receptor | 26s Proteasome,Akt,AR | 3 | Inhibited | -7.445 | 1.44E-10 | 0.0324 | 291 (93) | 93 |
38 | FLT4 | transmembrane receptor | 26s Proteasome,Akt,AR | 3 | Inhibited | -5.020 | 1.46E-10 | 0.0177 | 280 (80) | 78 |
39 | Vegfr dimer | complex | 26s Proteasome,AKT1,AR | 3 | Inhibited | -7.071 | 1.59E-10 | 0.0178 | 242 (61) | 58 |
40 | lipopolysaccharide | chemical drug | lipopolysaccharide | 1 | Inhibited | -7.668 | 2.75E-10 | 0.0045 | 120 (1) | 1 |
41 | TEK | kinase | 26s Proteasome,ADRB2 | 3 | Inhibited | -4.954 | 3E-10 | 0.0124 | 274 (93) | 93 |
42 | LATS1 | kinase | 26s Proteasome,ARID4A | 3 | Activated | 4.680 | 3.43E-10 | 0.0322 | 250 (56) | 54 |
43 | NYAP1 | other | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -6.264 | 3.54E-10 | 0.0304 | 281 (86) | 85 |
44 | MYO16 | other | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -6.264 | 3.54E-10 | 0.0304 | 281 (86) | 85 |
45 | NYAP2 | other | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -6.264 | 3.54E-10 | 0.0304 | 281 (86) | 85 |
46 | IRS | group | 26s Proteasome,ADRB2 | 3 | Inhibited | -5.548 | 1.63E-09 | 0.0456 | 269 (77) | 74 |
47 | FAK-Src | complex | 26s Proteasome,ABL1,Akt | 3 | Inhibited | -6.839 | 2.41E-09 | 0.043 | 273 (90) | 86 |
48 | Plk | group | 26s Proteasome,Akt,AKT1 | 3 | Inhibited | -2.500 | 2.77E-09 | 0.0425 | 219 (55) | 50 |
49 | G-protein beta | group | 26s Proteasome,ADORA2A | 3 | Inhibited | -5.647 | 3.22E-09 | 0.0309 | 283 (103) | 99 |
50 | ADRA1B | G-protein coupled receptor | 26s Proteasome,ADRA1B | 3 | Inhibited | -6.238 | 4.49E-09 | 0.0406 | 278 (86) | 85 |
51 | IL2 | cytokine | IL2 | 1 | Inhibited | -4.619 | 8.23E-09 | 0.0004 | 48 (1) | 1 |
52 | propolis | biologic drug | 26s Proteasome,AKT1 | 3 | Inhibited | -2.829 | 1.78E-08 | 0.0482 | 231 (76) | 73 |
53 | exenatide | biologic drug | 26s Proteasome,Akt,AMPK | 3 | -1.432 | 2.36E-08 | 0.0088 | 236 (88) | 88 | |
54 | imidazole | chemical - endogenous mammalian | 26s Proteasome,ADORA2A | 3 | 1.091 | 2.79E-08 | 0.05 | 243 (75) | 70 | |
55 | LETM1 | other | Akt,AMPK,APP,AR | 3 | -1.023 | 0.000000069 | 0.036 | 215 (64) | 63 | |
56 | IL-2R | complex | IL-2R,IL2RA,IL2RG,JAK1 | 2 | Inhibited | -3.491 | 0.00000012 | 0.0103 | 84 (14) | 13 |
57 | IL23 | complex | IL12B,IL23,JAK2,MTOR | 2 | Inhibited | -7.155 | 0.000000165 | 0.0112 | 80 (9) | 9 |
58 | IL15 | cytokine | IL15 | 1 | Inhibited | -2.121 | 0.000000551 | 0.0009 | 32 (1) | 1 |
59 | TH17 Cytokine | group | IL17A,IL21,IL22,TH17 | 2 | Inhibited | -4.323 | 0.000000813 | 0.0037 | 39 (4) | 4 |
60 | IL4R | transmembrane receptor | IL4,IL4R,IRS1,IRS2,JAK | 2 | Inhibited | -4.503 | 0.00000102 | 0.0252 | 75 (13) | 12 |
61 | IL21 | cytokine | IL21 | 1 | Inhibited | -2.985 | 0.00000527 | 0.0028 | 22 (1) | 1 |
62 | SATB1 | transcription regulator | SATB1 | 1 | 1.528 | 0.00000669 | 0.0011 | 21 (1) | 1 | |
63 | cyclosporin A | biologic drug | cyclosporin A | 1 | 1.441 | 0.0000108 | 0.0163 | 39 (1) | 1 | |
64 | IL12RB2 | transmembrane receptor | IL12 (family),IL12RB2 | 2 | Inhibited | -4.116 | 0.0000233 | 0.0103 | 34 (4) | 3 |
65 | mir-26 | microRNA | Akt,mir-26 | 2 | 0.192 | 0.0000247 | 0.0126 | 27 (2) | 2 | |
66 | mir-221 | microRNA | Akt,mir-221 | 2 | -0.192 | 0.0000247 | 0.0129 | 27 (2) | 2 | |
67 | IL5 | cytokine | IL5 | 1 | Inhibited | -4.914 | 0.0000541 | 0.0136 | 28 (1) | 1 |
68 | ropivacaine | chemical drug | Akt,NOS3,Pkc(s) | 2 | -1.029 | 0.0000544 | 0.0289 | 34 (5) | 4 | |
69 | UCP3 | transporter | IRS1,IRS2,PI3K | 2 | -1.961 | 0.0000657 | 0.0231 | 26 (4) | 3 | |
70 | AIF1 | other | AIF1,Akt,BAD | 2 | -1.177 | 0.0000657 | 0.0211 | 26 (3) | 3 | |
71 | IFN Beta | group | IFN Beta | 1 | Inhibited | -2.138 | 0.00082 | 0.043 | 14 (1) | 1 |
72 | PDGFD | growth factor | PDGFD | 1 | -0.577 | 0.000838 | 0.0044 | 3 (1) | 1 | |
73 | PARP9 | enzyme | PARP9 | 1 | Inhibited | -2.236 | 0.00123 | 0.0073 | 5 (1) | 1 |
74 | PPP1R14B | phosphatase | PPP1R14B | 1 | -1.732 | 0.00162 | 0.005 | 3 (1) | 1 |