Table 7 Effect of δ-tocotrienol on up-regulation of fold change expression in “upstream regulator” section (57) of IPA analysis in hepatitis C patients
Upstream Regulator | Molecule Type | Predicted Activation State | Activation Z-Score | P-value of overlap | Mechanistic Network | |
|---|---|---|---|---|---|---|
# | Up-regulated | |||||
1 | miR-17-5p (and other miRNAs w/seed AAAGUGC) | mature microrna | Activated | 3.798 | 5.39E-08 | 127 (7) |
2 | miR-155-5p (miRNAs w/seed UAAUGCU) | mature microrna | Activated | 4.518 | 9.04E-06 | 137 (7) |
3 | miR-19b-3p (and other miRNAs w/seed GUGCAAA) | mature microrna | Activated | 2.198 | 0.00017 | |
4 | miR-92a-3p (and other miRNAs w/seed AUUGCAC) | mature microrna | Activated | 2.187 | 0.00744 | |
5 | miR-214-3p (and other miRNAs w/seed CAGCAGG) | mature microrna | 0.0113 | |||
6 | miR-291a-3p (and other miRNAs w/seed AAGUGCU) | mature microrna | Activated | 2.994 | 0.017 | |
7 | miR-21-5p (and other miRNAs w/seed AGCUUAU) | mature microrna | Activated | 2.595 | 0.0159 | |
8 | miR-330-5p (and other miRNAs w/seed CUCUGGG) | mature microrna | 0.0113 | |||
9 | miR-122-5p (miRNAs w/seed GGAGUGU) | mature microrna | Activated | 2.586 | 0.0279 | |
10 | miR-2682-5p (and other miRNAs w/seed AGGCAGU) | mature microrna | 0.00584 | |||
11 | miR-205-5p (and other miRNAs w/seed CCUUCAU) | mature microrna | 0.0325 | |||
12 | miR-200b-3p (and other miRNAs w/seed AAUACUG) | mature microrna | 1.960 | 0.0273 | ||
13 | miR-542-3p (miRNAs w/seed GUGACAG) | mature microrna | 0.0363 | |||
14 | miR-221-3p (and other miRNAs w/seed GCUACAU) | mature microrna | 1.957 | 0.0349 | ||
15 | miR-147a (miRNAs w/seed UGUGUGG) | mature microrna | 0.0448 | |||
16 | miR-450a-5p (and other miRNAs w/seed UUUGCGA) | mature microrna | 0.0448 | |||
17 | miR-216a-5p (miRNAs w/seed AAUCUCA) | mature microrna | 0.0448 | |||
18 | miR-504-5p (and other miRNAs w/seed GACCCUG) | mature microrna | 0.0448 | |||
19 | miR-657 (miRNAs w/seed GCAGGUU) | mature microrna | 0.0448 | |||
20 | mir-17 | microrna | Activated | 2.581 | 0.00091 | |
21 | mir-122 | microrna | Activated | 3.300 | 0.00189 | |
22 | mir-19 | microrna | Activated | 2.204 | 0.002 | |
23 | mir-1 | microrna | Activated | 2.72 | 0.00354 | 128 (6) |
24 | mir-214 | microrna | 0.00906 | |||
25 | mir-326 | microrna | 0.0113 | |||
26 | mir-138 | microrna | 0.0113 | |||
27 | mir-32 | microrna | 0.0113 | |||
28 | mir-155 | microrna | 1.965 | 0.00691 | 173 (8) | |
29 | mir-148 | microrna | 1.997 | 0.00103 | ||
30 | mir-199 | microrna | 0.0028 | 164 (7) | ||
31 | mir-218 | microrna | 0.0183 | |||
32 | mir-515 | microrna | 0.0225 | |||
33 | mir-132 | microrna | 0.0349 | |||
34 | mir-10 | microrna | Activated | 2.786 | 0.0366 | |
35 | mir-8 | microrna | Activated | 2.128 | 0.0344 | |
36 | mir-25 | microrna | 1.972 | 0.0349 | ||
37 | mir-622 | microrna | 0.0448 | |||
38 | mir-181 | microrna | 0.988 | 0.0498 | ||
39 | Immunoglobulin | complex | Activated | 2.345 | 0.00024 | 283 (16) |
40 | prednisolone | chemical drug | 1.763 | 0.00025 | 235 (13) | |
41 | 26s Proteasome | complex | Activated | 2.921 | 0.000933 | 326 (16) |
42 | IgG | complex | 1.003 | 0.00824 | 295 (16) | |
43 | TRAP1 | enzyme | Activated | 2.236 | 0.0169 | |
44 | IL1RN | cytokine | Activated | 3.235 | 0.0275 | |
45 | prostaglandin A1 | chemical - endogenous non-mammalian | 0.686 | 0.00249 | 159 (8) | |
46 | AGTR1 | g-protein coupled receptor | 1.067 | 0.0291 | ||
47 | MAPK1 | kinase | 1.017 | 0.0361 | ||
48 | Ubiquitin | group | 0.039 | |||
49 | IL18RAP | transmembrane receptor | 0.0363 | |||
50 | TAB1 | enzyme | 1.258 | 0.0349 | ||
51 | eIF2B | complex | 0.0448 | |||
52 | SNRPN | other | 0.0448 | |||
53 | SNORD21 | other | 0.0448 | |||
54 | SOS2 | other | 0.0448 | |||
55 | IL1RL2 | transmembrane receptor | 0.0469 | |||
56 | IL18BP | other | 0.0469 | |||
57 | IL10RA | transmembrane receptor | Activated | 2.688 | 0.229 | |