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Table 7 Effect of δ-tocotrienol on up-regulation of fold change expression in “upstream regulator” section (57) of IPA analysis in hepatitis C patients

From: δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients

Upstream Regulator Molecule Type Predicted Activation State Activation Z-Score P-value of overlap Mechanistic Network
# Up-regulated
1 miR-17-5p (and other miRNAs w/seed AAAGUGC) mature microrna Activated 3.798 5.39E-08 127 (7)
2 miR-155-5p (miRNAs w/seed UAAUGCU) mature microrna Activated 4.518 9.04E-06 137 (7)
3 miR-19b-3p (and other miRNAs w/seed GUGCAAA) mature microrna Activated 2.198 0.00017  
4 miR-92a-3p (and other miRNAs w/seed AUUGCAC) mature microrna Activated 2.187 0.00744  
5 miR-214-3p (and other miRNAs w/seed CAGCAGG) mature microrna    0.0113  
6 miR-291a-3p (and other miRNAs w/seed AAGUGCU) mature microrna Activated 2.994 0.017  
7 miR-21-5p (and other miRNAs w/seed AGCUUAU) mature microrna Activated 2.595 0.0159  
8 miR-330-5p (and other miRNAs w/seed CUCUGGG) mature microrna    0.0113  
9 miR-122-5p (miRNAs w/seed GGAGUGU) mature microrna Activated 2.586 0.0279  
10 miR-2682-5p (and other miRNAs w/seed AGGCAGU) mature microrna    0.00584  
11 miR-205-5p (and other miRNAs w/seed CCUUCAU) mature microrna    0.0325  
12 miR-200b-3p (and other miRNAs w/seed AAUACUG) mature microrna   1.960 0.0273  
13 miR-542-3p (miRNAs w/seed GUGACAG) mature microrna    0.0363  
14 miR-221-3p (and other miRNAs w/seed GCUACAU) mature microrna   1.957 0.0349  
15 miR-147a (miRNAs w/seed UGUGUGG) mature microrna    0.0448  
16 miR-450a-5p (and other miRNAs w/seed UUUGCGA) mature microrna    0.0448  
17 miR-216a-5p (miRNAs w/seed AAUCUCA) mature microrna    0.0448  
18 miR-504-5p (and other miRNAs w/seed GACCCUG) mature microrna    0.0448  
19 miR-657 (miRNAs w/seed GCAGGUU) mature microrna    0.0448  
20 mir-17 microrna Activated 2.581 0.00091  
21 mir-122 microrna Activated 3.300 0.00189  
22 mir-19 microrna Activated 2.204 0.002  
23 mir-1 microrna Activated 2.72 0.00354 128 (6)
24 mir-214 microrna    0.00906  
25 mir-326 microrna    0.0113  
26 mir-138 microrna    0.0113  
27 mir-32 microrna    0.0113  
28 mir-155 microrna   1.965 0.00691 173 (8)
29 mir-148 microrna   1.997 0.00103  
30 mir-199 microrna    0.0028 164 (7)
31 mir-218 microrna    0.0183  
32 mir-515 microrna    0.0225  
33 mir-132 microrna    0.0349  
34 mir-10 microrna Activated 2.786 0.0366  
35 mir-8 microrna Activated 2.128 0.0344  
36 mir-25 microrna   1.972 0.0349  
37 mir-622 microrna    0.0448  
38 mir-181 microrna   0.988 0.0498  
39 Immunoglobulin complex Activated 2.345 0.00024 283 (16)
40 prednisolone chemical drug   1.763 0.00025 235 (13)
41 26s Proteasome complex Activated 2.921 0.000933 326 (16)
42 IgG complex   1.003 0.00824 295 (16)
43 TRAP1 enzyme Activated 2.236 0.0169  
44 IL1RN cytokine Activated 3.235 0.0275  
45 prostaglandin A1 chemical - endogenous non-mammalian   0.686 0.00249 159 (8)
46 AGTR1 g-protein coupled receptor   1.067 0.0291  
47 MAPK1 kinase   1.017 0.0361  
48 Ubiquitin group    0.039  
49 IL18RAP transmembrane receptor    0.0363  
50 TAB1 enzyme   1.258 0.0349  
51 eIF2B complex    0.0448  
52 SNRPN other    0.0448  
53 SNORD21 other    0.0448  
54 SOS2 other    0.0448  
55 IL1RL2 transmembrane receptor    0.0469  
56 IL18BP other    0.0469  
57 IL10RA transmembrane receptor Activated 2.688 0.229