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Table 2 Comparison of Association of Individual SNPs and Gene Score with Obesity

From: Use of a gene score of multiple low-modest effect size variants can predict the risk of obesity better than the individual SNPs

Gene SNP/GS OR p-value
GRB14 rs3923113 0.903 0.598
ST6GAL1 rs16861329 0.586 0.007
VPS26A rs1802295 1.366 0.087
AP3S2 rs2028299 1.351 0.094
HNF4A rs4812829 1.429 0.047
HMG20A rs7178572 1.149 0.373
FABP2 Ala54Thr 1.379 0.045
LEP G2548A 1.560 0.006
LEPR Gln223Arg 1.379 0.045
FTO rs1121980 1.346 0.089
Gene Score 1.175 0.0001
  1. The OR for the individual SNPs and the p-values indicate a marginal or no association with the outcome, however, when a gene score is used, the association with obesity becomes significant