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Table 1 Concentrations of various anti-oxidants, lipid peroxides and nitric oxide in pancreatic tissue in vivo

From: Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats

Summary of the analysis of various anti-oxidant/lipid peroxides and nitric oxide levels in pancreas of stz treated diabetic rats

Tissue

Group

SOD (Units/mg protein)

CAT (mM H2O2/min/mg protein

GST (mM/min/gm protein)

GPX (mM/min/gm protein)

LPO

(μM TMOP)

Nitric oxide

(μM nitrite)

Pancreas

[in vivo)

Control

36.9 ± 1.9

911 ± 62.8

19.58 ± 0.40

116.5 ± 2.6

1.3 ± 0.05

1.1 ± 0.02

STZ [65 mg/kg)

74.4 ± 3.2*

1494 ± 41*

54.8 ± 0.36*

191 ± 3.9*

1.5 ± 0.1*

1.6 ± 0.8*

  1. Superoxide dismutase (SOD) is expressed as U SOD/mg of protein; Catalase (CAT) is expressed as μM of H2O2 consumed/minute/mg of protein; Glutathione-S-transferase (GST) is expressed as μM conjugate formed/ minute/gm of protein; Glutathione peroxidase (GPX) is expressed as μg of glutathione consumed/minute/gm of protein. Lipid peroxides formed are expressed as μmoles of TMOP formed; Nitric oxide formed is expressed *P < 0.05, vs untreated control Vs respective STZ-treated group. All the above set of experiments done on n = 8 animal experiment in vivo. All values expressed as mean ± SEM