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Table 2 The effect of magnesium and vitamin E co-supplementation on metabolic status in women with gestational diabetes

From: The effects of magnesium and vitamin E co-supplementation on parameters of glucose homeostasis and lipid profiles in patients with gestational diabetes

VariablesPlacebo group (n = 30)Magnesium plus vitamin E group (n = 30)Difference in outcome measures between intervention and placebo treatment groups1
BaselineWeek 6BaselineWeek 6β (95% CI)P2
Magnesium (mg/dL)2.07 ± 0.152.02 ± 0.152.04 ± 0.222.18 ± 0.130.17 (0.11, 0.23)< 0.001
FPG (mg/dL)91.9 ± 5.691.8 ± 6.490.3 ± 6.285.4 ± 5.9−5.20 (−7.88, −2.52)0.002
Insulin (μIU/mL)13.4 ± 4.114.9 ± 8.913.2 ± 3.611.5 ± 3.7−2.93 (−5.68, −0.18)0.02
HOMA-IR3.0 ± 0.93.3 ± 2.03.0 ± 0.82.4 ± 0.8−0.78 (−1.42, − 0.14)0.01
QUICKI0.32 ± 0.010.32 ± 0.020.32 ± 0.010.33 ± 0.020.01 (0.005, 0.02)0.002
Triglycerides (mg/dL)208.9 ± 52.154.2206.3 ± 63.5169.1 ± 65.9−50.31 (−67.58, −33.04)< 0.001
VLDL-cholesterol (mg/dL)41.8 ± 10.444.5 ± 10.841.2 ± 12.733.8 ± 13.2−10.06 (−13.51, −6.60)< 0.001
Total cholesterol (mg/dL)229.5 ± 41.2232.9 ± 42.4223.3 ± 49.0201.3 ± 46.7−26.10 (−41.88, − 10.33)0.004
LDL-cholesterol (mg/dL)130.3 ± 36.4131.6 ± 39.0127.9 ± 41.7113.4 ± 45.5−15.20 (−29.50, −0.91)0.03
HDL-cholesterol (mg/dL)57.4 ± 13.256.8 ± 11.354.1 ± 9.654.0 ± 8.70.70 (−3.07, 2.09)0.68
Total-/HDL-cholesterol ratio4.1 ± 1.04.2 ± 1.04.2 ± 0.83.8 ± 0.8−0.46 (−0.72, − 0.19)< 0.001
  1. Data are mean ± SDs
  2. 1”Outcome measures” refers to the change in values of measures of interest between baseline and week 6. β [difference in the mean outcomes measures between treatment groups (magnesium plus vitamin E group = 1 and placebo group = 0)]
  3. 2 P values represent the time × group interaction (computed by analysis of the repeated measures ANOVA)
  4. FPG, fasting plasma glucose; HOMA-IR, homeostasis model of assessment-insulin resistance; HDL-cholesterol, high density lipoprotein-cholesterol; LDL-cholesterol, low density lipoprotein-cholesterol; QUICKI, quantitative insulin sensitivity check index; VLDL-cholesterol, very low density lipoprotein-cholesterol