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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells

Fig. 3

Combination treatment with chymostatin and aliskiren prevented apoptosis in HK2 cells treated with PA. a Protein abundance of Bax and caspase-3 was upregulated after PA treatment, which was prevented by cotreatment with chymostatin and aliskiren, whereas the level of Bcl-2 was unchanged. b Corresponding densitometric analyses of the radio of Bax and Bcl-2. c Quantitative analysis the levels of cleaved caspase-3 protein normalized to β-actin. Representative results of three independent experiments are shown. CTL, controls; PA, palmitic acid treatment group; PA + CMT, palmitic acid plus chymostatin treatment; PA + Ali, palmitic acid plus aliskiren treatment; PA + CMT + Ali, palmitic acid plus chymostatin and aliskiren treatment. * p < 0.05 compared with controls; # p < 0.05 compared with PA

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Lipids in Health and Disease

ISSN: 1476-511X