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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Vitamin D receptor polymorphism rs2228570 is significantly associated with risk of dyslipidemia and serum LDL levels in Chinese Han population

Fig. 3

2D diagram of the changes in bound ligand conformations of the wild-type and mutant VDR. The superposition of 1,25(OH)2D3 molecules is shown in gray: Circles represent the amino acids of the receptor molecule. Blue halos around the circles denote the solvent-accessible surface of the interacting residue. The dashed lines indicate the hydrogen-bond interactions between the ligands and the receptor molecule. The green dashed lines represent hydrogen bond interactions with amino acid main chains; blue-dashed lines show the hydrogen bond interactions with the main chains of the amino acids (the arrow head is directed towards the electron donor). The numbers (e.g., 2.2) represent the hydrogen bond interaction distances: a Conformation derived from the VDR receptor wild-type model structure; b Conformation derived from the VDR receptor mutant model structure (MET1THR)

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