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Table 3 Univariate and HbA1c-adjusted analysis of risk factors and incidence of diabetes mellitus

From: Impact of serum cholesterol esterification rates on the development of diabetes mellitus in a general population

Variables

Univariate

HbA1c adjusted

RR* (95%CI)

P value

RR* (95%CI)

P value

Age

1.01 (0.99–1.03)

0.60

0.98 (0.96–1.00)

0.09

Man

1.99 (1.11–3.60)

0.02

1.60 (0.87–2.93)

0.13

History of Hypertension

1.50 (0.82–2.73)

0.19

1.39 (0.75–2.58)

0.33

Current smoker

1.72 (0.91–3.27)

0.10

1.39 (0.72–2.71)

0.33

BMI

8.04 (2.81–23.07)

<0.001

7.52 (2.58–21.90)

<0.001

Waist circumference

5.57 (2.12–14.63)

<0.001

4.23 (1.58–11.30)

0.004

Waist/hip

6.10 (2.09–17.80)

0.001

3.76 (1.26–11.22)

0.02

SBP

3.99 (1.47–10.81)

0.006

3.06 (1.11–8.45)

0.03

DBP

2.26 (1.06–4.82)

0.04

2.09 (0.96–4.57)

0.06

HbA1c

16.70 (3.98–70.14)

<0.001

  

Glucose

3.34 (1.32–8.47)

0.01

2.11 (0.81–5.50)

0.13

IRI

2.19 (0.93–5.13)

0.07

2.58 (1.07–6.23)

0.04

TC

1.75 (0.79–3.88)

0.17

1.17 (0.52–2.67)

0.70

HDL-C

0.16 (0.05–0.46)

0.001

0.18 (0.06–0.54)

0.002

TG

10.50 (3.17–34.76)

<0.001

8.11 (2.42–27.22)

0.001

Non-HDL-C

3.11 (1.31–7.41)

0.01

2.11 (0.86–5.14)

0.10

Phospholipids

3.30 (1.20–9.10)

0.02

2.66 (0.95–7.45)

0.06

Free fatty acids

1.00 (0.47–2.13)

1.00

1.01 (0.46–2.20)

0.98

LCAT activity

9.42 (2.82–31.39)

<0.001

7.37 (2.18-24.89)

0.001

  1. *RR indicates a relative risk for diabetes mellitus in quartile 4 subjects as compared with quartile 1 subjects for continuous variables except for age, which is expressed as a risk per one year increment. RR of Man indicates the risk of diabetes mellitus of men compared with that of women
  2. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c glycosylated hemoglobin A1c, IRI immunoreactive insulin, TC total cholesterol, HDL-C high-density lipoprotein-cholesterol, TG triglyceride, LCAT lecithin cholesterol acyltransferase