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Table 3 Univariate and HbA1c-adjusted analysis of risk factors and incidence of diabetes mellitus

From: Impact of serum cholesterol esterification rates on the development of diabetes mellitus in a general population

Variables Univariate HbA1c adjusted
RR* (95%CI) P value RR* (95%CI) P value
Age 1.01 (0.99–1.03) 0.60 0.98 (0.96–1.00) 0.09
Man 1.99 (1.11–3.60) 0.02 1.60 (0.87–2.93) 0.13
History of Hypertension 1.50 (0.82–2.73) 0.19 1.39 (0.75–2.58) 0.33
Current smoker 1.72 (0.91–3.27) 0.10 1.39 (0.72–2.71) 0.33
BMI 8.04 (2.81–23.07) <0.001 7.52 (2.58–21.90) <0.001
Waist circumference 5.57 (2.12–14.63) <0.001 4.23 (1.58–11.30) 0.004
Waist/hip 6.10 (2.09–17.80) 0.001 3.76 (1.26–11.22) 0.02
SBP 3.99 (1.47–10.81) 0.006 3.06 (1.11–8.45) 0.03
DBP 2.26 (1.06–4.82) 0.04 2.09 (0.96–4.57) 0.06
HbA1c 16.70 (3.98–70.14) <0.001   
Glucose 3.34 (1.32–8.47) 0.01 2.11 (0.81–5.50) 0.13
IRI 2.19 (0.93–5.13) 0.07 2.58 (1.07–6.23) 0.04
TC 1.75 (0.79–3.88) 0.17 1.17 (0.52–2.67) 0.70
HDL-C 0.16 (0.05–0.46) 0.001 0.18 (0.06–0.54) 0.002
TG 10.50 (3.17–34.76) <0.001 8.11 (2.42–27.22) 0.001
Non-HDL-C 3.11 (1.31–7.41) 0.01 2.11 (0.86–5.14) 0.10
Phospholipids 3.30 (1.20–9.10) 0.02 2.66 (0.95–7.45) 0.06
Free fatty acids 1.00 (0.47–2.13) 1.00 1.01 (0.46–2.20) 0.98
LCAT activity 9.42 (2.82–31.39) <0.001 7.37 (2.18-24.89) 0.001
  1. *RR indicates a relative risk for diabetes mellitus in quartile 4 subjects as compared with quartile 1 subjects for continuous variables except for age, which is expressed as a risk per one year increment. RR of Man indicates the risk of diabetes mellitus of men compared with that of women
  2. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c glycosylated hemoglobin A1c, IRI immunoreactive insulin, TC total cholesterol, HDL-C high-density lipoprotein-cholesterol, TG triglyceride, LCAT lecithin cholesterol acyltransferase